2.50
Hdl Handle:
http://hdl.handle.net/10547/594767
Title:
The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat.
Authors:
Thomas, E. Louise; Parkinson, James R.; Frost, Gary S.; Goldstone, Anthony P. ( 0000-0001-8179-7071 ) ; Doré, Caroline J.; McCarthy, John; Collins, Adam L.; Fitzpatrick, Julie; Durighel, Giuliana; Taylor-Robinson, Simon D.; Bell, Jimmy D. ( 0000-0003-3804-1281 )
Abstract:
Individual compartments of abdominal adiposity and lipid content within the liver and muscle are differentially associated with metabolic risk factors, obesity and insulin resistance. Subjects with greater intra-abdominal adipose tissue (IAAT) and hepatic fat than predicted by clinical indices of obesity may be at increased risk of metabolic diseases despite their "normal" size. There is a need for accurate quantification of these potentially hazardous depots and identification of novel subphenotypes that recognize individuals at potentially increased metabolic risk. We aimed to calculate a reference range for total and regional adipose tissue (AT) as well as ectopic fat in liver and muscle in healthy subjects. We studied the relationship between age, body-mass, BMI, waist circumference (WC), and the distribution of AT, using whole-body magnetic resonance imaging (MRI), in 477 white volunteers (243 male, 234 female). Furthermore, we used proton magnetic resonance spectroscopy (MRS) to determine intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid content. The anthropometric variable which provided the strongest individual correlation for adiposity and ectopic fat stores was WC in men and BMI in women. In addition, we reveal a large variation in IAAT, abdominal subcutaneous AT (ASAT), and IHCL depots not fully predicted by clinically obtained measurements of obesity and the emergence of a previously unidentified subphenotype. Here, we demonstrate gender- and age-specific patterns of regional adiposity in a large UK-based cohort and identify anthropometric variables that best predict individual adiposity and ectopic fat stores. From these data we propose the thin-on-the-outside fat-on-the-inside (TOFI) as a subphenotype for individuals at increased metabolic risk.
Affiliation:
Imperial College London
Citation:
Thomas, E.L. et al (2012) 'The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat' Obesity 20 (1):76-87
Publisher:
Wiley
Journal:
Obesity (Silver Spring, Md.)
Issue Date:
Jan-2012
URI:
http://hdl.handle.net/10547/594767
DOI:
10.1038/oby.2011.142
PubMed ID:
21660078
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.142/full
Type:
Article
Language:
en
ISSN:
1930-739X
Appears in Collections:
Muscle Cellular and Molecular Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, E. Louiseen
dc.contributor.authorParkinson, James R.en
dc.contributor.authorFrost, Gary S.en
dc.contributor.authorGoldstone, Anthony P.en
dc.contributor.authorDoré, Caroline J.en
dc.contributor.authorMcCarthy, Johnen
dc.contributor.authorCollins, Adam L.en
dc.contributor.authorFitzpatrick, Julieen
dc.contributor.authorDurighel, Giulianaen
dc.contributor.authorTaylor-Robinson, Simon D.en
dc.contributor.authorBell, Jimmy D.en
dc.date.accessioned2016-01-25T11:01:22Zen
dc.date.available2016-01-25T11:01:22Zen
dc.date.issued2012-01en
dc.identifier.citationThomas, E.L. et al (2012) 'The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat' Obesity 20 (1):76-87en
dc.identifier.issn1930-739Xen
dc.identifier.pmid21660078en
dc.identifier.doi10.1038/oby.2011.142en
dc.identifier.urihttp://hdl.handle.net/10547/594767en
dc.description.abstractIndividual compartments of abdominal adiposity and lipid content within the liver and muscle are differentially associated with metabolic risk factors, obesity and insulin resistance. Subjects with greater intra-abdominal adipose tissue (IAAT) and hepatic fat than predicted by clinical indices of obesity may be at increased risk of metabolic diseases despite their "normal" size. There is a need for accurate quantification of these potentially hazardous depots and identification of novel subphenotypes that recognize individuals at potentially increased metabolic risk. We aimed to calculate a reference range for total and regional adipose tissue (AT) as well as ectopic fat in liver and muscle in healthy subjects. We studied the relationship between age, body-mass, BMI, waist circumference (WC), and the distribution of AT, using whole-body magnetic resonance imaging (MRI), in 477 white volunteers (243 male, 234 female). Furthermore, we used proton magnetic resonance spectroscopy (MRS) to determine intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid content. The anthropometric variable which provided the strongest individual correlation for adiposity and ectopic fat stores was WC in men and BMI in women. In addition, we reveal a large variation in IAAT, abdominal subcutaneous AT (ASAT), and IHCL depots not fully predicted by clinically obtained measurements of obesity and the emergence of a previously unidentified subphenotype. Here, we demonstrate gender- and age-specific patterns of regional adiposity in a large UK-based cohort and identify anthropometric variables that best predict individual adiposity and ectopic fat stores. From these data we propose the thin-on-the-outside fat-on-the-inside (TOFI) as a subphenotype for individuals at increased metabolic risk.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1038/oby.2011.142/fullen
dc.rightsArchived with thanks to Obesity (Silver Spring, Md.)en
dc.subjectMRIen
dc.subjectMRSen
dc.subjectmagnetic resonance imagingen
dc.subjectintra-abdominal adipose tissueen
dc.subjecthepatic faten
dc.subject.meshAdipose Tissueen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshBody Compositionen
dc.subject.meshBody Mass Indexen
dc.subject.meshChoristomaen
dc.subject.meshCohort Studiesen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshGreat Britainen
dc.subject.meshHumansen
dc.subject.meshInsulin Resistanceen
dc.subject.meshLiveren
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMagnetic Resonance Spectroscopyen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshObesityen
dc.subject.meshPhenotypeen
dc.subject.meshReference Valuesen
dc.subject.meshRisk Factorsen
dc.subject.meshSubcutaneous Fat, Abdominalen
dc.subject.meshYoung Adulten
dc.titleThe missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat.en
dc.typeArticleen
dc.contributor.departmentImperial College Londonen
dc.identifier.journalObesity (Silver Spring, Md.)en

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