Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells

2.50
Hdl Handle:
http://hdl.handle.net/10547/593536
Title:
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
Authors:
Uysal-Onganer, Pinar ( 0000-0003-3190-8831 ) ; Kawano, Yoshiaki; Caro, Mercedes; Walker, Marjorie M.; Diez, Soraya; Darrington, R. Siobhan ( 0000-0002-5671-3259 ) ; Waxman, Jonathan; Kypta, Robert M. ( 0000-0002-2389-310X )
Abstract:
Wnt-11 is a secreted protein that modulates cell growth, differentiation and morphogenesis during development. We previously reported that Wnt-11 expression is elevated in hormone-independent prostate cancer and that the progression of prostate cancer from androgen-dependent to androgen-independent proliferation correlates with a loss of mutual inhibition between Wnt-11- and androgen receptor-dependent signals. However, the prevalence of increased expression of Wnt-11 in patient tumours and the functions of Wnt-11 in prostate cancer cells were not known.
Citation:
Uysal-Onganer, P. et al (2010) 'Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells' Mol. Cancer 9:55
Publisher:
BioMed Central
Journal:
Molecular cancer
Issue Date:
2010
URI:
http://hdl.handle.net/10547/593536
DOI:
10.1186/1476-4598-9-55
PubMed ID:
20219091
PubMed Central ID:
PMC2846888
Additional Links:
http://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-55
Type:
Article
Language:
en
ISSN:
1476-4598
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorUysal-Onganer, Pinaren
dc.contributor.authorKawano, Yoshiakien
dc.contributor.authorCaro, Mercedesen
dc.contributor.authorWalker, Marjorie M.en
dc.contributor.authorDiez, Sorayaen
dc.contributor.authorDarrington, R. Siobhanen
dc.contributor.authorWaxman, Jonathanen
dc.contributor.authorKypta, Robert M.en
dc.date.accessioned2016-01-15T12:25:57Zen
dc.date.available2016-01-15T12:25:57Zen
dc.date.issued2010en
dc.identifier.citationUysal-Onganer, P. et al (2010) 'Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells' Mol. Cancer 9:55en
dc.identifier.issn1476-4598en
dc.identifier.pmid20219091en
dc.identifier.doi10.1186/1476-4598-9-55en
dc.identifier.urihttp://hdl.handle.net/10547/593536en
dc.description.abstractWnt-11 is a secreted protein that modulates cell growth, differentiation and morphogenesis during development. We previously reported that Wnt-11 expression is elevated in hormone-independent prostate cancer and that the progression of prostate cancer from androgen-dependent to androgen-independent proliferation correlates with a loss of mutual inhibition between Wnt-11- and androgen receptor-dependent signals. However, the prevalence of increased expression of Wnt-11 in patient tumours and the functions of Wnt-11 in prostate cancer cells were not known.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-55en
dc.rightsArchived with thanks to Molecular canceren
dc.subjectWnt-11en
dc.subjectprostate canceren
dc.subjectcancer cellsen
dc.subject.meshAndrogensen
dc.subject.meshApoptosisen
dc.subject.meshCell Differentiationen
dc.subject.meshCell Line, Tumoren
dc.subject.meshCell Movementen
dc.subject.meshCell Survivalen
dc.subject.meshDown-Regulationen
dc.subject.meshGene Expression Regulation, Neoplasticen
dc.subject.meshGene Silencingen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshNeoplasm Invasivenessen
dc.subject.meshNeuroendocrine Cellsen
dc.subject.meshProstatic Neoplasmsen
dc.subject.meshWnt Proteinsen
dc.titleWnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cellsen
dc.typeArticleen
dc.identifier.journalMolecular canceren
dc.identifier.pmcidPMC2846888en

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