Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)

2.50
Hdl Handle:
http://hdl.handle.net/10547/593475
Title:
Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)
Authors:
Fülster, Susann; Tacke, Matthias; Sandek, Anja; Ebner, Nicole; Tschöpe, Carsten; Doehner, Wolfram; Anker, Stefan D.; von Haehling, Stephan
Abstract:
Aims To assess the prevalence and clinical impact of reductions in the skeletal muscle mass of patients with chronic heart failure (HF). Chronic HF is accompanied by co-morbidities that influence the quality of life and outcomes. Methods and results We prospectively enrolled 200 patients with chronic HF. The appendicular skeletal muscle mass of the arms and the legs combined, was assessed by dual energy X-ray absorptiometry. We analysed the muscle strength in arms and legs, and all patients underwent a 6-min walk test, a 4-m walk test, and spiroergometry testing. Muscle wasting was defined as the appendicular muscle mass 2 SD below the mean of a healthy reference group of adults aged 18–40 years, as suggested for the diagnosis of muscle wasting in healthy ageing (sarcopenia). Muscle wasting was detected in 39 (19.5%) subjects. Patients with muscle wasting had significantly lower values for handgrip and quadriceps strength as well as lower total peak oxygen consumption (peakVO2, 1173 ± 433 vs. 1622 ± 456 mL/min), lower exercise time (7.7 ± 3.8 vs. 10.22 ± 3.0 min, both P < 0.001), and lower left ventricular ejection fraction (LVEF, P = 0.05) than patients without. The distance walked during 6 min and the gait speed during the 4-m walk were lower in patients with muscle wasting (both P < 0.05). Serum levels of interleukin-6 were significantly elevated in patients with muscle wasting (P = 0.001). Logistic regression showed muscle wasting to be independently associated with reduced peak VO2 adjusted for age, sex, New York Heart Association class, haemoglobin, LVEF, distance walked in 6 minutes, and the number of co-morbidities (odds ratio 6.53, p = 0.01). Conclusion Muscle wasting is a frequent co-morbidity among patients with chronic HF. Patients with muscle wasting present with reduced exercise capacity and muscle strength, and advanced disease.
Citation:
Fülster, S. et al (2012) 'Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)' European heart journal 34(7):512-9
Publisher:
Oxford University Press
Journal:
European heart journal
Issue Date:
23-Nov-2012
URI:
http://hdl.handle.net/10547/593475
DOI:
dx.doi.org/10.1093/eurheartj/ehs381
PubMed ID:
23178647
Additional Links:
http://eurheartj.oxfordjournals.org/content/34/7/512
Type:
Article
Language:
en
ISSN:
0195-668x
EISSN:
1522-9645
Appears in Collections:
IHR Institute for Health Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFülster, Susannen
dc.contributor.authorTacke, Matthiasen
dc.contributor.authorSandek, Anjaen
dc.contributor.authorEbner, Nicoleen
dc.contributor.authorTschöpe, Carstenen
dc.contributor.authorDoehner, Wolframen
dc.contributor.authorAnker, Stefan D.en
dc.contributor.authorvon Haehling, Stephanen
dc.date.accessioned2016-01-14T13:35:13Zen
dc.date.available2016-01-14T13:35:13Zen
dc.date.issued2012-11-23en
dc.identifier.citationFülster, S. et al (2012) 'Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)' European heart journal 34(7):512-9en
dc.identifier.issn0195-668xen
dc.identifier.pmid23178647en
dc.identifier.doidx.doi.org/10.1093/eurheartj/ehs381en
dc.identifier.urihttp://hdl.handle.net/10547/593475en
dc.description.abstractAims To assess the prevalence and clinical impact of reductions in the skeletal muscle mass of patients with chronic heart failure (HF). Chronic HF is accompanied by co-morbidities that influence the quality of life and outcomes. Methods and results We prospectively enrolled 200 patients with chronic HF. The appendicular skeletal muscle mass of the arms and the legs combined, was assessed by dual energy X-ray absorptiometry. We analysed the muscle strength in arms and legs, and all patients underwent a 6-min walk test, a 4-m walk test, and spiroergometry testing. Muscle wasting was defined as the appendicular muscle mass 2 SD below the mean of a healthy reference group of adults aged 18–40 years, as suggested for the diagnosis of muscle wasting in healthy ageing (sarcopenia). Muscle wasting was detected in 39 (19.5%) subjects. Patients with muscle wasting had significantly lower values for handgrip and quadriceps strength as well as lower total peak oxygen consumption (peakVO2, 1173 ± 433 vs. 1622 ± 456 mL/min), lower exercise time (7.7 ± 3.8 vs. 10.22 ± 3.0 min, both P < 0.001), and lower left ventricular ejection fraction (LVEF, P = 0.05) than patients without. The distance walked during 6 min and the gait speed during the 4-m walk were lower in patients with muscle wasting (both P < 0.05). Serum levels of interleukin-6 were significantly elevated in patients with muscle wasting (P = 0.001). Logistic regression showed muscle wasting to be independently associated with reduced peak VO2 adjusted for age, sex, New York Heart Association class, haemoglobin, LVEF, distance walked in 6 minutes, and the number of co-morbidities (odds ratio 6.53, p = 0.01). Conclusion Muscle wasting is a frequent co-morbidity among patients with chronic HF. Patients with muscle wasting present with reduced exercise capacity and muscle strength, and advanced disease.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://eurheartj.oxfordjournals.org/content/34/7/512en
dc.subjectheart failureen
dc.subjectmuscle wastingen
dc.subjectsarcopeniaen
dc.subjectsymptomsen
dc.subjectquality of lifeen
dc.titleMuscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)en
dc.typeArticleen
dc.identifier.eissn1522-9645en
dc.identifier.journalEuropean heart journalen

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