TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

2.50
Hdl Handle:
http://hdl.handle.net/10547/593473
Title:
TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy
Authors:
Baumgarten, Anna; Bang, Claudia; Tschirner, Anika; Engelmann, Anke; Adams, Volker; von Haehling, Stephan; Doehner, Wolfram; Pregla, Reinhard; Anker, Markus S.; Blecharz, Kinga; Meyer, Rudolf; Hetzer, Roland; Anker, Stefan D.; Thum, Thomas; Springer, Jochen
Abstract:
The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.
Affiliation:
Charité Medical School; Medical School Hannover; Heart Center Leipzig; German Heart Center Berlin; IRCCS San Raffaele; University of East Anglia
Citation:
Baumgarten, A. et al (2013) 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy' Int. J. Cardiol. 168 (2):1447-52
Publisher:
Elsevier
Journal:
International journal of cardiology
Issue Date:
30-Sep-2013
URI:
http://hdl.handle.net/10547/593473
DOI:
10.1016/j.ijcard.2012.12.094
PubMed ID:
23360823
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0167527313000053
Type:
Article
Language:
en
ISSN:
1874-1754
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorBaumgarten, Annaen
dc.contributor.authorBang, Claudiaen
dc.contributor.authorTschirner, Anikaen
dc.contributor.authorEngelmann, Ankeen
dc.contributor.authorAdams, Volkeren
dc.contributor.authorvon Haehling, Stephanen
dc.contributor.authorDoehner, Wolframen
dc.contributor.authorPregla, Reinharden
dc.contributor.authorAnker, Markus S.en
dc.contributor.authorBlecharz, Kingaen
dc.contributor.authorMeyer, Rudolfen
dc.contributor.authorHetzer, Rolanden
dc.contributor.authorAnker, Stefan D.en
dc.contributor.authorThum, Thomasen
dc.contributor.authorSpringer, Jochenen
dc.date.accessioned2016-01-15T11:06:34Zen
dc.date.available2016-01-15T11:06:34Zen
dc.date.issued2013-09-30en
dc.identifier.citationBaumgarten, A. et al (2013) 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy' Int. J. Cardiol. 168 (2):1447-52en
dc.identifier.issn1874-1754en
dc.identifier.pmid23360823en
dc.identifier.doi10.1016/j.ijcard.2012.12.094en
dc.identifier.urihttp://hdl.handle.net/10547/593473en
dc.description.abstractThe transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0167527313000053en
dc.rightsArchived with thanks to International journal of cardiologyen
dc.subjectTWIST1en
dc.subjectubiquitin proteasome systemen
dc.subjectdilated cardiomyopathyen
dc.subjecttranscriptionen
dc.subject.meshAdulten
dc.subject.meshAnimalsen
dc.subject.meshAnimals, Newbornen
dc.subject.meshCardiomyopathy, Dilateden
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMicroRNAsen
dc.subject.meshMiddle Ageden
dc.subject.meshNuclear Proteinsen
dc.subject.meshProteasome Endopeptidase Complexen
dc.subject.meshRatsen
dc.subject.meshTwist Transcription Factoren
dc.subject.meshUbiquitinen
dc.titleTWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathyen
dc.typeArticleen
dc.contributor.departmentCharité Medical Schoolen
dc.contributor.departmentMedical School Hannoveren
dc.contributor.departmentHeart Center Leipzigen
dc.contributor.departmentGerman Heart Center Berlinen
dc.contributor.departmentIRCCS San Raffaeleen
dc.contributor.departmentUniversity of East Angliaen
dc.identifier.journalInternational journal of cardiologyen

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