Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

2.50
Hdl Handle:
http://hdl.handle.net/10547/593469
Title:
Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia
Authors:
Palus, Sandra; von Haehling, Stephan; Flach, Valerie C.; Tschirner, Anika; Doehner, Wolfram; Anker, Stefan D.; Springer, Jochen
Abstract:
Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.
Affiliation:
Charité Medical School; IRCCS San Raffaele; University of East Anglia
Citation:
Palus, S. et al (2013) 'Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia' Int. J. Cardiol. 168 (4):3412-8
Publisher:
Elsevier
Journal:
International journal of cardiology
Issue Date:
9-Oct-2013
URI:
http://hdl.handle.net/10547/593469
DOI:
10.1016/j.ijcard.2013.04.150
PubMed ID:
23680591
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0167527313007997
Type:
Article
Language:
en
ISSN:
1874-1754
Appears in Collections:
IHR Institute for Health Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPalus, Sandraen
dc.contributor.authorvon Haehling, Stephanen
dc.contributor.authorFlach, Valerie C.en
dc.contributor.authorTschirner, Anikaen
dc.contributor.authorDoehner, Wolframen
dc.contributor.authorAnker, Stefan D.en
dc.contributor.authorSpringer, Jochenen
dc.date.accessioned2016-01-15T09:55:10Zen
dc.date.available2016-01-15T09:55:10Zen
dc.date.issued2013-10-09en
dc.identifier.citationPalus, S. et al (2013) 'Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia' Int. J. Cardiol. 168 (4):3412-8en
dc.identifier.issn1874-1754en
dc.identifier.pmid23680591en
dc.identifier.doi10.1016/j.ijcard.2013.04.150en
dc.identifier.urihttp://hdl.handle.net/10547/593469en
dc.description.abstractChronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0167527313007997en
dc.rightsArchived with thanks to International journal of cardiologyen
dc.subjectsimvastatinen
dc.subjectbody compositionen
dc.subjectcancer cachexiaen
dc.subjectcardiac functionen
dc.subjecthepatomaen
dc.subjectsurvivalen
dc.subject.meshAnimalsen
dc.subject.meshCachexiaen
dc.subject.meshCardiac Outputen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshHeart Rateen
dc.subject.meshNeoplasmsen
dc.subject.meshRandom Allocationen
dc.subject.meshRatsen
dc.subject.meshRats, Wistaren
dc.subject.meshSimvastatinen
dc.subject.meshStroke Volumeen
dc.subject.meshTreatment Outcomeen
dc.titleSimvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexiaen
dc.typeArticleen
dc.contributor.departmentCharité Medical Schoolen
dc.contributor.departmentIRCCS San Raffaeleen
dc.contributor.departmentUniversity of East Angliaen
dc.identifier.journalInternational journal of cardiologyen

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