Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia.

2.50
Hdl Handle:
http://hdl.handle.net/10547/581937
Title:
Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia.
Authors:
Janczar, K.; Janczar, Szymon; Pastorczak, A.; Mycko, K.; Paige, Adam J.W.; Zalewska-Szewczyk, B.; Wagrowska-Danilewicz, M.; Danilewicz, M.; Mlynarski, W.
Abstract:
Epigenetic dysregulation is a hallmark of cancer executed by a number of complex processes the most important of which converge on DNA methylation and histone protein modifications. Epigenetic marks are potentially reversible and thus promising drug targets. In the setting of acute lymphoblastic leukemia (ALL) they have been associated with clinicopathological features including risk of relapse or molecular subgroups of the disease. Here, using immunocytochemistry of bone marrow smears from diagnosis, we studied global histone H4 acetylation, whose loss was previously linked to treatment failure in adults with ALL, in pediatric patients. We demonstrate that preserved global histone H4 acetylation is significantly associated with favorable outcome (RFS, EFS, OS) in children with B cell progenitor (BCP) ALL, recapitulating the findings from adult populations. Further, for the first time we demonstrate differential histone H4 acetylation in molecular subclasses of BCP-ALL including cases with ETV6-RUNX1 fusion gene or PAX5 deletion or deletions in genes linked to B cell development. We conclude global histone H4 acetylation is a prognostic marker and a potential therapeutic target in ALL.
Affiliation:
Medical University of Lodz; University of Bedfordshire
Citation:
Janczar, K., Janczar, S., Pastorczak, K., Mycko, K., Paige, A.J.W., Zalewska-Szewczyk, Wagrowska-Danilewicz, M., Mlynarski, W. (2015) ' Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia' Leukemia Research Oct 20. pii: S0145-2126(15)30531-2. doi: 10.1016/j.leukres.2015.10.006. [Epub ahead of print]
Publisher:
Elsevier
Journal:
Leukemia research
Issue Date:
20-Oct-2015
URI:
http://hdl.handle.net/10547/581937
DOI:
10.1016/j.leukres.2015.10.006
PubMed ID:
26520622
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0145212615305312; http://www.ncbi.nlm.nih.gov/pubmed/26520622
Type:
Article
Language:
en
ISSN:
1873-5835
Appears in Collections:
Biomedical Science

Full metadata record

DC FieldValue Language
dc.contributor.authorJanczar, K.en
dc.contributor.authorJanczar, Szymonen
dc.contributor.authorPastorczak, A.en
dc.contributor.authorMycko, K.en
dc.contributor.authorPaige, Adam J.W.en
dc.contributor.authorZalewska-Szewczyk, B.en
dc.contributor.authorWagrowska-Danilewicz, M.en
dc.contributor.authorDanilewicz, M.en
dc.contributor.authorMlynarski, W.en
dc.date.accessioned2015-11-09T12:09:00Zen
dc.date.available2015-11-09T12:09:00Zen
dc.date.issued2015-10-20en
dc.identifier.citationJanczar, K., Janczar, S., Pastorczak, K., Mycko, K., Paige, A.J.W., Zalewska-Szewczyk, Wagrowska-Danilewicz, M., Mlynarski, W. (2015) ' Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia' Leukemia Research Oct 20. pii: S0145-2126(15)30531-2. doi: 10.1016/j.leukres.2015.10.006. [Epub ahead of print]en
dc.identifier.issn1873-5835en
dc.identifier.pmid26520622en
dc.identifier.doi10.1016/j.leukres.2015.10.006en
dc.identifier.urihttp://hdl.handle.net/10547/581937en
dc.description.abstractEpigenetic dysregulation is a hallmark of cancer executed by a number of complex processes the most important of which converge on DNA methylation and histone protein modifications. Epigenetic marks are potentially reversible and thus promising drug targets. In the setting of acute lymphoblastic leukemia (ALL) they have been associated with clinicopathological features including risk of relapse or molecular subgroups of the disease. Here, using immunocytochemistry of bone marrow smears from diagnosis, we studied global histone H4 acetylation, whose loss was previously linked to treatment failure in adults with ALL, in pediatric patients. We demonstrate that preserved global histone H4 acetylation is significantly associated with favorable outcome (RFS, EFS, OS) in children with B cell progenitor (BCP) ALL, recapitulating the findings from adult populations. Further, for the first time we demonstrate differential histone H4 acetylation in molecular subclasses of BCP-ALL including cases with ETV6-RUNX1 fusion gene or PAX5 deletion or deletions in genes linked to B cell development. We conclude global histone H4 acetylation is a prognostic marker and a potential therapeutic target in ALL.en
dc.languageENGen
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0145212615305312en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26520622en
dc.rightsArchived with thanks to Leukemia researchen
dc.subjectacute lymphoblastic leukemiaen
dc.subjectepigeneticsen
dc.subjecthistone acetylationen
dc.subjectleukaemiaen
dc.titlePreserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia.en
dc.typeArticleen
dc.contributor.departmentMedical University of Lodzen
dc.contributor.departmentUniversity of Bedfordshireen
dc.identifier.journalLeukemia researchen

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