The interaction of wnt-11 and signalling cascades in prostate cancer

2.50
Hdl Handle:
http://hdl.handle.net/10547/344606
Title:
The interaction of wnt-11 and signalling cascades in prostate cancer
Authors:
Koushyar, Sarah
Abstract:
Castration resistant prostate cancer proposes an array of issues in terms of treatment options. It is therefore necessary to decipher the underlying mechanism involved in androgen independent prostate cancer and neuroendocrine differentiation, which is associated with malignant and metastatic disease. Wnt-11 has been previously shown to be associated with the more malignant version of the disease by being involved in the cellular proliferation and differentiation of the cancerous cells. The methodology adopted to identify signalling pathways triggered upon Wnt-11 activation were inhibition of the JNK, PKA, PI3K and mTOR pathway with various concentrations of inhibitors, proceeding this proliferation, migration and gene expression experiments were carried out three times, each experiment containing a triplet of each condition. Results collected were significant in all experiments excluding the proliferation results involving the PKA pathway. A preliminary mechanism was established between Wnt-11 and the mentioned pathways with neuroendocrine differentiation. The experiments carried out along with the correlated data were novel and brings research one step closer to understanding the mechanism of androgen independent prostate cancer, which in turn can hopefully relay to new therapy options which are currently absent on the market.
Citation:
Koushyar, S. (2014) 'The interaction of wnt-11 and signalling cascades in prostate cancer'. Masters by Research thesis. University of Bedfordshire.
Publisher:
University of Bedfordshire
Issue Date:
Jul-2014
URI:
http://hdl.handle.net/10547/344606
Type:
Thesis or dissertation
Language:
en
Description:
A thesis submitted to the University of Bedfordshire, in fulfilment of the requirements for the degree of Masters by Research
Appears in Collections:
Masters e-theses

Full metadata record

DC FieldValue Language
dc.contributor.authorKoushyar, Sarahen
dc.date.accessioned2015-02-20T14:21:23Zen
dc.date.available2015-02-20T14:21:23Zen
dc.date.issued2014-07en
dc.identifier.citationKoushyar, S. (2014) 'The interaction of wnt-11 and signalling cascades in prostate cancer'. Masters by Research thesis. University of Bedfordshire.en
dc.identifier.urihttp://hdl.handle.net/10547/344606en
dc.descriptionA thesis submitted to the University of Bedfordshire, in fulfilment of the requirements for the degree of Masters by Researchen
dc.description.abstractCastration resistant prostate cancer proposes an array of issues in terms of treatment options. It is therefore necessary to decipher the underlying mechanism involved in androgen independent prostate cancer and neuroendocrine differentiation, which is associated with malignant and metastatic disease. Wnt-11 has been previously shown to be associated with the more malignant version of the disease by being involved in the cellular proliferation and differentiation of the cancerous cells. The methodology adopted to identify signalling pathways triggered upon Wnt-11 activation were inhibition of the JNK, PKA, PI3K and mTOR pathway with various concentrations of inhibitors, proceeding this proliferation, migration and gene expression experiments were carried out three times, each experiment containing a triplet of each condition. Results collected were significant in all experiments excluding the proliferation results involving the PKA pathway. A preliminary mechanism was established between Wnt-11 and the mentioned pathways with neuroendocrine differentiation. The experiments carried out along with the correlated data were novel and brings research one step closer to understanding the mechanism of androgen independent prostate cancer, which in turn can hopefully relay to new therapy options which are currently absent on the market.en
dc.language.isoenen
dc.publisherUniversity of Bedfordshireen
dc.subjectB130 Pathologyen
dc.subjectprostate canceren
dc.subjectWnt-11en
dc.subjectandrogen independent prostate canceren
dc.titleThe interaction of wnt-11 and signalling cascades in prostate canceren
dc.typeThesis or dissertationen
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