Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells
Abstract
The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN.Citation
Chaudhry, Z.L. and Ahmed, B.Y. (2012) 'Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells', Neurological Research 35(4) 435-440Publisher
Maney PublishingJournal
Neurological ResearchAdditional Links
http://www.ingentaconnect.com/content/maney/nres/pre-prints/1743132812Y.0000000135aType
ArticleLanguage
enISSN
0161-6412ae974a485f413a2113503eed53cd6c53
10.1179/1743132812Y.0000000135a