2.50
Hdl Handle:
http://hdl.handle.net/10547/302093
Title:
Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation
Authors:
Tokuda, Masaaki; Ahmed, Bushra Y.; Lu, Yun-Fei; Matsui, Hideki; Miyamoto, Osamu; Yamaguchi, Fuminori; Konishi, Ryoji; Hatase, Osamu
Abstract:
Multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are thought to be involved in the induction of long-term potentiation (LTP). In the present study, LTP was induced by theta burst stimulation in the Schaffer collateral area of the stratum radiatum in the hippocampal CA1 region of the rat hippocampus. LTP-induced and control hippocampal slices were studied by Western blot and immunohistochemical analyses using CaMK-I, -II and -IV antibodies. Increased amounts of all three CaMKs were found in LTP-induced hippocampal slices as indicated by Western blot as well as by the density of their immunoreactivity. Our data clearly shows that not only CaMK-II but also CaMK-I and -IV contribute to synaptic plasticity formed in LTP.
Citation:
Tokuda M., Ahmed B. Y., Miyamoto O., Lu Y-F., Matsui H., and Hatase O. (1997) 'Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation', Brain Research, 755(1),pp.162-166
Publisher:
Elsevier
Journal:
Brain Research
Issue Date:
1997
URI:
http://hdl.handle.net/10547/302093
DOI:
10.1016/S0006-8993(97)00189-3
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0006899397001893
Type:
Article
Language:
en
ISSN:
0006-8993
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorTokuda, Masaakien_GB
dc.contributor.authorAhmed, Bushra Y.en_GB
dc.contributor.authorLu, Yun-Feien_GB
dc.contributor.authorMatsui, Hidekien_GB
dc.contributor.authorMiyamoto, Osamuen_GB
dc.contributor.authorYamaguchi, Fuminorien_GB
dc.contributor.authorKonishi, Ryojien_GB
dc.contributor.authorHatase, Osamuen_GB
dc.date.accessioned2013-09-23T11:57:56Z-
dc.date.available2013-09-23T11:57:56Z-
dc.date.issued1997-
dc.identifier.citationTokuda M., Ahmed B. Y., Miyamoto O., Lu Y-F., Matsui H., and Hatase O. (1997) 'Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation', Brain Research, 755(1),pp.162-166en_GB
dc.identifier.issn0006-8993-
dc.identifier.doi10.1016/S0006-8993(97)00189-3-
dc.identifier.urihttp://hdl.handle.net/10547/302093-
dc.description.abstractMultifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are thought to be involved in the induction of long-term potentiation (LTP). In the present study, LTP was induced by theta burst stimulation in the Schaffer collateral area of the stratum radiatum in the hippocampal CA1 region of the rat hippocampus. LTP-induced and control hippocampal slices were studied by Western blot and immunohistochemical analyses using CaMK-I, -II and -IV antibodies. Increased amounts of all three CaMKs were found in LTP-induced hippocampal slices as indicated by Western blot as well as by the density of their immunoreactivity. Our data clearly shows that not only CaMK-II but also CaMK-I and -IV contribute to synaptic plasticity formed in LTP.en_GB
dc.language.isoenen
dc.publisherElsevieren_GB
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0006899397001893en_GB
dc.rightsArchived with thanks to Brain Researchen_GB
dc.subjectlong-term potentiationen_GB
dc.subjectCa2+/calmodulin-dependent protein kinaseen_GB
dc.subjecthippocampusen_GB
dc.titleInvolvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiationen
dc.typeArticleen
dc.identifier.journalBrain Researchen_GB
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