Authors
Zhang, AipingSkaar, David A.
Li, Yue
Huang, Dale
Price, Thomas M.
Murphy, Susan K.
Jirtle, Randy L.
Issue Date
2011
Metadata
Show full item recordAbstract
Differentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 50-end of FAM50B at 6p25.2. We determined that sense transcripts originating from the FAM50B locus are expressed from the paternal allele in all human tissues investigated except for ovary, in which expression is biallelic. Furthermore, an antisense transcript, FAM50B-AS, was identified to be monoallelically expressed from the paternal allele in a variety of tissues. Comparative phylogenetic analysis showed that FAM50B orthologs are absent in chicken and platypus, but are present and biallelically expressed in opossum and mouse.Citation
Zhang, A., Skaar, D.A., Li,Y, et al. (2011) 'Novel retrotransposed imprinted locus identified at human 6p25', Nucleic Acids Research, 39(13), pp.5388-5400Publisher
Oxford University PressJournal
Nucleic Acids ResearchAdditional Links
http://www.nar.oxfordjournals.org/cgi/doi/10.1093/nar/gkr108Type
ArticleLanguage
enISSN
0305-10481362-4962
ae974a485f413a2113503eed53cd6c53
10.1093/nar/gkr108