2.50
Hdl Handle:
http://hdl.handle.net/10547/296168
Title:
Novel retrotransposed imprinted locus identified at human 6p25
Authors:
Zhang, Aiping; Skaar, David A.; Li, Yue; Huang, Dale; Price, Thomas M.; Murphy, Susan K. ( 0000-0001-8298-7272 ) ; Jirtle, Randy L. ( 0000-0003-1767-045X )
Abstract:
Differentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 50-end of FAM50B at 6p25.2. We determined that sense transcripts originating from the FAM50B locus are expressed from the paternal allele in all human tissues investigated except for ovary, in which expression is biallelic. Furthermore, an antisense transcript, FAM50B-AS, was identified to be monoallelically expressed from the paternal allele in a variety of tissues. Comparative phylogenetic analysis showed that FAM50B orthologs are absent in chicken and platypus, but are present and biallelically expressed in opossum and mouse.
Citation:
Zhang, A., Skaar, D.A., Li,Y, et al. (2011) 'Novel retrotransposed imprinted locus identified at human 6p25', Nucleic Acids Research, 39(13), pp.5388-5400
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research
Issue Date:
2011
URI:
http://hdl.handle.net/10547/296168
DOI:
10.1093/nar/gkr108
Additional Links:
http://www.nar.oxfordjournals.org/cgi/doi/10.1093/nar/gkr108
Type:
Article
Language:
en
ISSN:
0305-1048; 1362-4962
Appears in Collections:
Muscle Cellular and Molecular Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Aipingen_GB
dc.contributor.authorSkaar, David A.en_GB
dc.contributor.authorLi, Yueen_GB
dc.contributor.authorHuang, Daleen_GB
dc.contributor.authorPrice, Thomas M.en_GB
dc.contributor.authorMurphy, Susan K.en_GB
dc.contributor.authorJirtle, Randy L.en_GB
dc.date.accessioned2013-07-16T10:17:45Z-
dc.date.available2013-07-16T10:17:45Z-
dc.date.issued2011-
dc.identifier.citationZhang, A., Skaar, D.A., Li,Y, et al. (2011) 'Novel retrotransposed imprinted locus identified at human 6p25', Nucleic Acids Research, 39(13), pp.5388-5400en_GB
dc.identifier.issn0305-1048-
dc.identifier.issn1362-4962-
dc.identifier.doi10.1093/nar/gkr108-
dc.identifier.urihttp://hdl.handle.net/10547/296168-
dc.description.abstractDifferentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 50-end of FAM50B at 6p25.2. We determined that sense transcripts originating from the FAM50B locus are expressed from the paternal allele in all human tissues investigated except for ovary, in which expression is biallelic. Furthermore, an antisense transcript, FAM50B-AS, was identified to be monoallelically expressed from the paternal allele in a variety of tissues. Comparative phylogenetic analysis showed that FAM50B orthologs are absent in chicken and platypus, but are present and biallelically expressed in opossum and mouse.en_GB
dc.language.isoenen
dc.publisherOxford University Pressen_GB
dc.relation.urlhttp://www.nar.oxfordjournals.org/cgi/doi/10.1093/nar/gkr108en_GB
dc.rightsArchived with thanks to Nucleic Acids Researchen_GB
dc.titleNovel retrotransposed imprinted locus identified at human 6p25en
dc.typeArticleen
dc.identifier.journalNucleic Acids Researchen_GB
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