Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

2.50
Hdl Handle:
http://hdl.handle.net/10547/296166
Title:
Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
Authors:
Soubry, Adelheid; Schildkraut, Joellen M.; Murtha, Amy; Wang, Frances; Huang, Zhiqing; Bernal, Autumn J.; Kurtzberg, Joanne ( 0000-0002-3370-0703 ) ; Jirtle, Randy L. ( 0000-0003-1767-045X ) ; Murphy, Susan K. ( 0000-0001-8298-7272 ) ; Hoyo, Cathrine ( 0000-0002-2466-8617 )
Abstract:
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic machinery. Besides in vitro environmental exposures, the possible impact on the reprogramming of methylation profiles at imprinted genes at a much earlier time point, such as during spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene.
Affiliation:
Duke University Medical Center
Citation:
Soubry, A., Schildkraut, J.M., Murtha, A. et al. (2013) 'Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort', BMC medicine, 11 (1) pp.1-10.
Publisher:
BioMed Central
Journal:
BMC medicine
Issue Date:
2013
URI:
http://hdl.handle.net/10547/296166
DOI:
10.1186/1741-7015-11-29
PubMed ID:
23388414
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/23388414; http://www.biomedcentral.com/1741-7015/11/29/
Type:
Article
Language:
en
ISSN:
1741-7015
Appears in Collections:
Muscle Cellular and Molecular Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorSoubry, Adelheiden_GB
dc.contributor.authorSchildkraut, Joellen M.en_GB
dc.contributor.authorMurtha, Amyen_GB
dc.contributor.authorWang, Francesen_GB
dc.contributor.authorHuang, Zhiqingen_GB
dc.contributor.authorBernal, Autumn J.en_GB
dc.contributor.authorKurtzberg, Joanneen_GB
dc.contributor.authorJirtle, Randy L.en_GB
dc.contributor.authorMurphy, Susan K.en_GB
dc.contributor.authorHoyo, Cathrineen_GB
dc.date.accessioned2013-07-16T10:15:07Zen
dc.date.available2013-07-16T10:15:07Zen
dc.date.issued2013en
dc.identifier.citationSoubry, A., Schildkraut, J.M., Murtha, A. et al. (2013) 'Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort', BMC medicine, 11 (1) pp.1-10.en_GB
dc.identifier.issn1741-7015en
dc.identifier.pmid23388414en
dc.identifier.doi10.1186/1741-7015-11-29en
dc.identifier.urihttp://hdl.handle.net/10547/296166en
dc.description.abstractData from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic machinery. Besides in vitro environmental exposures, the possible impact on the reprogramming of methylation profiles at imprinted genes at a much earlier time point, such as during spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene.en_GB
dc.language.isoenen
dc.publisherBioMed Centralen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23388414en_GB
dc.relation.urlhttp://www.biomedcentral.com/1741-7015/11/29/en
dc.rightsArchived with thanks to BMC medicineen_GB
dc.subjectepigeneticsen_GB
dc.subjectDNA methylationen_GB
dc.subjectobesityen_GB
dc.titlePaternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohorten
dc.typeArticleen
dc.contributor.departmentDuke University Medical Centeren
dc.identifier.journalBMC medicineen_GB

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