Variation in basal heat shock protein 70 is correlated to core temperature in human subjects.

2.50
Hdl Handle:
http://hdl.handle.net/10547/295070
Title:
Variation in basal heat shock protein 70 is correlated to core temperature in human subjects.
Authors:
Sandström, Marie E.; Madden, Leigh A.; Taylor, Lee; Siegler, Jason C.; Lovell, Ric J.; Midgley, Adrian; McNaughton, Lars
Abstract:
Heat shock proteins are highly conserved proteins and play an important chaperone role in aiding the folding of nascent proteins within cells. The heat shock protein response to various stressors, both in vitro and in vivo, is well characterised. However, basal levels of heat shock protein 70 (Hsp70) have not previously been investigated. Monocyte-expressed Hsp70 was determined every 4 h, over a 24 h time period, in 17 healthy male subjects (177 +/- 6.4 cm, 75.7 +/- 10.9 kg, 19.8 +/- 4.3 years) within a temperature and activity controlled environment. Core temperature was measured at 5-min intervals during the 24 h period. Hsp70 showed significant diurnal variation (F = 7.4; p < 0.001), demonstrating peaks at 0900 and 2100 hours, and a nadir at 05.00. Core temperature followed a similar temporal trend (range = 35.96-38.10 degrees C) and was significantly correlated with Hsp70 expression (r(s) = 0.44; p < 0.001). These findings suggest a high responsiveness of Hsp70 expression in monocytes to slight variations in core temperature.
Citation:
Sandstrom, M. E., Madden, L. A., Taylor, L., Siegler, J. C., Lovell, R. J., Midgley, A. W. & Mcnaughton, L. (2009) 'Variation in basal heat shock protein 70 is correlated to core temperature in human subjects', Amino Acids, 37 (2), pp. 279-284.
Publisher:
Springer
Journal:
Amino acids
Issue Date:
Jul-2009
URI:
http://hdl.handle.net/10547/295070
DOI:
10.1007/s00726-008-0144-4
PubMed ID:
18665435
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18665435
Type:
Article
Language:
en
ISSN:
1438-2199
Appears in Collections:
Applied Sport and Exercise Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorSandström, Marie E.en_GB
dc.contributor.authorMadden, Leigh A.en_GB
dc.contributor.authorTaylor, Leeen_GB
dc.contributor.authorSiegler, Jason C.en_GB
dc.contributor.authorLovell, Ric J.en_GB
dc.contributor.authorMidgley, Adrianen_GB
dc.contributor.authorMcNaughton, Larsen_GB
dc.date.accessioned2013-07-02T15:41:53Z-
dc.date.available2013-07-02T15:41:53Z-
dc.date.issued2009-07-
dc.identifier.citationSandstrom, M. E., Madden, L. A., Taylor, L., Siegler, J. C., Lovell, R. J., Midgley, A. W. & Mcnaughton, L. (2009) 'Variation in basal heat shock protein 70 is correlated to core temperature in human subjects', Amino Acids, 37 (2), pp. 279-284.en_GB
dc.identifier.issn1438-2199-
dc.identifier.pmid18665435-
dc.identifier.doi10.1007/s00726-008-0144-4-
dc.identifier.urihttp://hdl.handle.net/10547/295070-
dc.description.abstractHeat shock proteins are highly conserved proteins and play an important chaperone role in aiding the folding of nascent proteins within cells. The heat shock protein response to various stressors, both in vitro and in vivo, is well characterised. However, basal levels of heat shock protein 70 (Hsp70) have not previously been investigated. Monocyte-expressed Hsp70 was determined every 4 h, over a 24 h time period, in 17 healthy male subjects (177 +/- 6.4 cm, 75.7 +/- 10.9 kg, 19.8 +/- 4.3 years) within a temperature and activity controlled environment. Core temperature was measured at 5-min intervals during the 24 h period. Hsp70 showed significant diurnal variation (F = 7.4; p < 0.001), demonstrating peaks at 0900 and 2100 hours, and a nadir at 05.00. Core temperature followed a similar temporal trend (range = 35.96-38.10 degrees C) and was significantly correlated with Hsp70 expression (r(s) = 0.44; p < 0.001). These findings suggest a high responsiveness of Hsp70 expression in monocytes to slight variations in core temperature.en_GB
dc.language.isoenen
dc.publisherSpringeren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18665435en_GB
dc.rightsArchived with thanks to Amino acidsen_GB
dc.subjectC600 Sports Scienceen_GB
dc.subject.meshAdolescent-
dc.subject.meshBody Temperature-
dc.subject.meshCircadian Rhythm-
dc.subject.meshHSP70 Heat-Shock Proteins-
dc.subject.meshHeart Rate-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMonocytes-
dc.subject.meshYoung Adult-
dc.titleVariation in basal heat shock protein 70 is correlated to core temperature in human subjects.en
dc.typeArticleen
dc.identifier.journalAmino acidsen_GB

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