Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise

2.50
Hdl Handle:
http://hdl.handle.net/10547/295057
Title:
Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise
Authors:
Peart, Daniel J.; McNaughton, Lars R.; Midgley, Adrian W.; Taylor, Lee; Towlson, Christopher; Madden, Leigh A.; Vince, Rebecca V.
Abstract:
The heat shock protein 72 (HSP72) response following exercise is well documented, however, little is known on whether the expression may be mediated by the ingestion of ergogenic aids prior to performance. The purpose of this research was to investigate the effect of sodium bicarbonate (NaHCO(3)) ingestion on monocyte and lymphocyte expressed HSP72 and oxidative stress for 4-h post exercise. Seven active males (22.3 ± 2.9 years, 181.6 ± 4.5 cm, 78.1 ± 8.1 kg) performed a 4-min 'all-out' cycle test following a dose of 0.3 g kg(-1) body mass of NaHCO(3), or an equimolar placebo dose of sodium chloride. HSP72 was measured by flow cytometry and oxidative stress was determined via plasma thiobarbituric acid substances (TBARS) analysis. The NaHCO(3) ingestion significantly increased blood pH (p<0.001), bicarbonate (p<0.001) and base excess (p<0.001) pre-exercise. Despite this there was no evidence of a significantly improved exercise performance when compared with the placebo trials (p ≥ 0.26) (means ± SD; average power 292 ± 43 W vs. 291 ± 50 W; peak power 770 ± 218 W vs. 775 ± 211 W; work completed 71 ± 10 kJ vs. 68 ± 10 kJ). Monocyte expressed HSP72 was significantly lower under experimental conditions during the 4-h post-exercise (p=0.013), as was plasma TBARS (p<0.001). These findings suggest that pre-exercise alkalosis can attenuate the stress response to a single bout of anaerobic exercise.
Citation:
Peart, D. McNaughton, L. Midgley, A. Taylor, L. Towlson, C. Madden, L. and Vince, R. (2011) 'Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise', Journal of Science and Medicine in Sport, 14, pp. 435-440.
Publisher:
Elsevier
Journal:
Journal of Science and Medicine in Sport
Issue Date:
Sep-2011
URI:
http://hdl.handle.net/10547/295057
DOI:
10.1016/j.jsams.2011.03.006
PubMed ID:
21498114
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21498114
Type:
Article
Language:
en
ISSN:
1878-1861
Appears in Collections:
Applied Sport and Exercise Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorPeart, Daniel J.en_GB
dc.contributor.authorMcNaughton, Lars R.en_GB
dc.contributor.authorMidgley, Adrian W.en_GB
dc.contributor.authorTaylor, Leeen_GB
dc.contributor.authorTowlson, Christopheren_GB
dc.contributor.authorMadden, Leigh A.en_GB
dc.contributor.authorVince, Rebecca V.en_GB
dc.date.accessioned2013-07-02T15:53:55Z-
dc.date.available2013-07-02T15:53:55Z-
dc.date.issued2011-09-
dc.identifier.citationPeart, D. McNaughton, L. Midgley, A. Taylor, L. Towlson, C. Madden, L. and Vince, R. (2011) 'Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise', Journal of Science and Medicine in Sport, 14, pp. 435-440.en_GB
dc.identifier.issn1878-1861-
dc.identifier.pmid21498114-
dc.identifier.doi10.1016/j.jsams.2011.03.006-
dc.identifier.urihttp://hdl.handle.net/10547/295057-
dc.description.abstractThe heat shock protein 72 (HSP72) response following exercise is well documented, however, little is known on whether the expression may be mediated by the ingestion of ergogenic aids prior to performance. The purpose of this research was to investigate the effect of sodium bicarbonate (NaHCO(3)) ingestion on monocyte and lymphocyte expressed HSP72 and oxidative stress for 4-h post exercise. Seven active males (22.3 ± 2.9 years, 181.6 ± 4.5 cm, 78.1 ± 8.1 kg) performed a 4-min 'all-out' cycle test following a dose of 0.3 g kg(-1) body mass of NaHCO(3), or an equimolar placebo dose of sodium chloride. HSP72 was measured by flow cytometry and oxidative stress was determined via plasma thiobarbituric acid substances (TBARS) analysis. The NaHCO(3) ingestion significantly increased blood pH (p<0.001), bicarbonate (p<0.001) and base excess (p<0.001) pre-exercise. Despite this there was no evidence of a significantly improved exercise performance when compared with the placebo trials (p ≥ 0.26) (means ± SD; average power 292 ± 43 W vs. 291 ± 50 W; peak power 770 ± 218 W vs. 775 ± 211 W; work completed 71 ± 10 kJ vs. 68 ± 10 kJ). Monocyte expressed HSP72 was significantly lower under experimental conditions during the 4-h post-exercise (p=0.013), as was plasma TBARS (p<0.001). These findings suggest that pre-exercise alkalosis can attenuate the stress response to a single bout of anaerobic exercise.en_GB
dc.language.isoenen
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21498114en_GB
dc.rightsArchived with thanks to Journal of science and medicine in sport / Sports Medicine Australiaen_GB
dc.subjectC600 Sports Scienceen_GB
dc.subject.meshAdult-
dc.subject.meshAlkalosis-
dc.subject.meshAthletic Performance-
dc.subject.meshExercise-
dc.subject.meshExercise Test-
dc.subject.meshHSP72 Heat-Shock Proteins-
dc.subject.meshHumans-
dc.subject.meshHydrogen-Ion Concentration-
dc.subject.meshLactic Acid-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshMonocytes-
dc.subject.meshOxidative Stress-
dc.subject.meshSodium Bicarbonate-
dc.subject.meshThiobarbituric Acid Reactive Substances-
dc.subject.meshYoung Adult-
dc.titlePre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exerciseen
dc.typeArticleen
dc.identifier.journalJournal of Science and Medicine in Sporten_GB

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