2.50
Hdl Handle:
http://hdl.handle.net/10547/294911
Title:
The effect of the hyperbaric environment on heat shock protein 72 expression in vivo
Authors:
Taylor, Lee; Midgley, Adrian W.; Sandstrom, Marie E.; Chrismas, Bryna; McNaughton, Lars R.
Abstract:
Heat shock protein 72 (HSP72) is expressed in response to stress and has been demonstrated to follow a diurnal expression pattern within monocytes and is sensitive to changes in core temperature. Numerous studies have shown changes in HSP72 expression within cell lines exposed to hyperbaric conditions. No studies have investigated changes in HSP72 expression in vivo. Six males participated in the study and were exposed to hyperbaric air and hyperbaric oxygen a week apart. Monocyte HSP72 was analyzed by flow cytometry at 09:00, 13:00, 17:00, 21:00 with hyperbaric oxygen or hyperbaric air breathing commencing at 15:00 for 78 min at a pressure of 2.8 ATA. HSP72 under normoxia followed the established trend; however, following the hyperbaric air or oxygen exposure a reduction in detectable HSP72 was observed at 17:00 and 21:00. No changes in core temperature were observed between 13:00 and 21:00 for any condition. The data show that HSP72 expression is impaired following hyperbaric air (HA) exposure, when compared with control or hyperbaric oxygen (HO) exposure.
Citation:
Taylor, L., Midgley, A, Sandstrom, M., Chrismas, B., & McNaughton, L. (2012) 'The effect of the hyperbaric environment on heat shock protein 72 expression in vivo', Research in Sports Medicine, 20 (2), pp. 142-53.
Publisher:
Taylor and Francis
Journal:
Research in sports medicine
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10547/294911
DOI:
10.1080/15438627.2012.660830
PubMed ID:
22458830
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/22458830
Type:
Article
Language:
en
ISSN:
1543-8635
Appears in Collections:
Applied Sport and Exercise Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorTaylor, Leeen_GB
dc.contributor.authorMidgley, Adrian W.en_GB
dc.contributor.authorSandstrom, Marie E.en_GB
dc.contributor.authorChrismas, Brynaen_GB
dc.contributor.authorMcNaughton, Lars R.en_GB
dc.date.accessioned2013-06-28T15:25:40Z-
dc.date.available2013-06-28T15:25:40Z-
dc.date.issued2012-04-
dc.identifier.citationTaylor, L., Midgley, A, Sandstrom, M., Chrismas, B., & McNaughton, L. (2012) 'The effect of the hyperbaric environment on heat shock protein 72 expression in vivo', Research in Sports Medicine, 20 (2), pp. 142-53.en_GB
dc.identifier.issn1543-8635-
dc.identifier.pmid22458830-
dc.identifier.doi10.1080/15438627.2012.660830-
dc.identifier.urihttp://hdl.handle.net/10547/294911-
dc.description.abstractHeat shock protein 72 (HSP72) is expressed in response to stress and has been demonstrated to follow a diurnal expression pattern within monocytes and is sensitive to changes in core temperature. Numerous studies have shown changes in HSP72 expression within cell lines exposed to hyperbaric conditions. No studies have investigated changes in HSP72 expression in vivo. Six males participated in the study and were exposed to hyperbaric air and hyperbaric oxygen a week apart. Monocyte HSP72 was analyzed by flow cytometry at 09:00, 13:00, 17:00, 21:00 with hyperbaric oxygen or hyperbaric air breathing commencing at 15:00 for 78 min at a pressure of 2.8 ATA. HSP72 under normoxia followed the established trend; however, following the hyperbaric air or oxygen exposure a reduction in detectable HSP72 was observed at 17:00 and 21:00. No changes in core temperature were observed between 13:00 and 21:00 for any condition. The data show that HSP72 expression is impaired following hyperbaric air (HA) exposure, when compared with control or hyperbaric oxygen (HO) exposure.en_GB
dc.language.isoenen
dc.publisherTaylor and Francisen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22458830en_GB
dc.rightsArchived with thanks to Research in sports medicine (Print)en_GB
dc.subjectC600 Sports Scienceen_GB
dc.subject.meshAdaptation, Physiological-
dc.subject.meshBody Temperature-
dc.subject.meshEnvironment-
dc.subject.meshFlow Cytometry-
dc.subject.meshHSP70 Heat-Shock Proteins-
dc.subject.meshHSP72 Heat-Shock Proteins-
dc.subject.meshHumans-
dc.subject.meshHyperbaric Oxygenation-
dc.subject.meshMale-
dc.subject.meshMonocytes-
dc.subject.meshOxidative Stress-
dc.subject.meshStress, Physiological-
dc.subject.meshTelemetry-
dc.subject.meshThiobarbiturates-
dc.subject.meshYoung Adult-
dc.titleThe effect of the hyperbaric environment on heat shock protein 72 expression in vivoen
dc.typeArticleen
dc.identifier.journalResearch in sports medicineen_GB

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