G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency

2.50
Hdl Handle:
http://hdl.handle.net/10547/294848
Title:
G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency
Authors:
Im, Jae Hong; Tapmeier, Thomas; Balathasan, Lukxmi; Gal, Annamaria; Yameen, Sabira; Hill, Sally; Smart, Sean; Noterdaeme, Olivier; Kelly, Matthew; Brady, Michael; Fu, Weili; Kruse, Karoline; Bernhard, Eric J.; Augustin, Hellmut G.; Muschel, Ruth J.
Abstract:
Suppression of neo-angiogenesis is a clinically used anti-tumor strategy with new targets such as angiopoietin-2 (Ang2) being proposed. However, the functions of Ang2 in vascular remodeling, inflammation and tumor growth are not consistent. We examined effect of depletion of host Ang2 on liver colony formation using Ang2 deficient (Ang22/2) mice.
Citation:
Im, J.H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., Fu, W., Kruse, K., Bernhard, E.J., Augustin, H.G. and Muschel, R.J. (2013) 'G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency', International Journal of Cancer, 132(2), pp.315-326.
Publisher:
Wiley
Journal:
International Journal of Cancer
Issue Date:
2013
URI:
http://hdl.handle.net/10547/294848
DOI:
10.1002/ijc.27677
Additional Links:
http://doi.wiley.com/10.1002/ijc.27677
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorIm, Jae Hongen_GB
dc.contributor.authorTapmeier, Thomasen_GB
dc.contributor.authorBalathasan, Lukxmien_GB
dc.contributor.authorGal, Annamariaen_GB
dc.contributor.authorYameen, Sabiraen_GB
dc.contributor.authorHill, Sallyen_GB
dc.contributor.authorSmart, Seanen_GB
dc.contributor.authorNoterdaeme, Olivieren_GB
dc.contributor.authorKelly, Matthewen_GB
dc.contributor.authorBrady, Michaelen_GB
dc.contributor.authorFu, Weilien_GB
dc.contributor.authorKruse, Karolineen_GB
dc.contributor.authorBernhard, Eric J.en_GB
dc.contributor.authorAugustin, Hellmut G.en_GB
dc.contributor.authorMuschel, Ruth J.en_GB
dc.date.accessioned2013-06-28T09:59:04Z-
dc.date.available2013-06-28T09:59:04Z-
dc.date.issued2013-
dc.identifier.citationIm, J.H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., Fu, W., Kruse, K., Bernhard, E.J., Augustin, H.G. and Muschel, R.J. (2013) 'G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency', International Journal of Cancer, 132(2), pp.315-326.en_GB
dc.identifier.issn0020-7136-
dc.identifier.doi10.1002/ijc.27677-
dc.identifier.urihttp://hdl.handle.net/10547/294848-
dc.description.abstractSuppression of neo-angiogenesis is a clinically used anti-tumor strategy with new targets such as angiopoietin-2 (Ang2) being proposed. However, the functions of Ang2 in vascular remodeling, inflammation and tumor growth are not consistent. We examined effect of depletion of host Ang2 on liver colony formation using Ang2 deficient (Ang22/2) mice.en_GB
dc.language.isoenen
dc.publisherWileyen_GB
dc.relation.urlhttp://doi.wiley.com/10.1002/ijc.27677en_GB
dc.rightsArchived with thanks to International Journal of Canceren_GB
dc.subjectangiopoietin-2en_GB
dc.subjectneutrophilsen_GB
dc.subjectangiogenesisen_GB
dc.subjectvascular leakageen_GB
dc.subjectmetastasisen_GB
dc.titleG-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiencyen
dc.typeArticleen
dc.identifier.journalInternational Journal of Canceren_GB
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