2.50
Hdl Handle:
http://hdl.handle.net/10547/294843
Title:
Molecular and cellular events in alcohol-induced muscle disease
Authors:
Fernandez-Solà, Joaquim; Preedy, Victor R.; Lang, Charles H.; Gonzalez-Reimers, Emilio; Arno, Matthew; Lin, J.C.I.; Wiseman, H.; Zhou, Shaobo ( 0000-0001-5214-2973 ) ; Emery, P.W.; Nakahara, T.; Hashimoto, K.; Hirano, M.; Santolaria-Fernández, F.; González-Hernández, T.; Fatjó, Francesc; Sacanella, Emilio; Estruch, Ramón; Nicolás, José M.; Urbano-Márquez, Alvaro
Abstract:
Alcohol consumption induces a dose-dependent noxious effect on skeletal muscle, leading to progressive functional and structural damage of myocytes, with concomitant reductions in lean body mass. Nearly half of high-dose chronic alcohol consumers develop alcoholic skeletal myopathy. The pathogenic mechanisms that lie between alcohol intake and loss of muscle tissue involve multiple pathways, making the elucidation of the disease somewhat difficult. This review discusses the recent advances in basic and clinical research on the molecular and cellular events involved in the development of alcohol-induced muscle disease. The main areas of recent research interest on this field are as follows: (i) molecular mechanisms in alcohol exposed muscle in the rat model; (ii) gene expression changes in alcohol exposed muscle; (iii) the role of trace elements and oxidative stress in alcoholic myopathy; and (iv) the role of apoptosis and preapoptotic pathways in alcoholic myopathy. These aforementioned areas are crucial in understanding the pathogenesis of this disease. For example, there is overwhelming evidence that both chronic alcohol ingestion and acute alcohol intoxication impair the rate of protein synthesis of myofibrillar proteins, in particular, under both postabsorptive and postprandial conditions. Perturbations in gene expression are contributory factors to the development of alcoholic myopathy, as ethanol-induced alterations are detected in over 400 genes and the protein profile (i.e., the proteome) of muscle is also affected. There is supportive evidence that oxidative damage is involved in the pathogenesis of alcoholic myopathy. Increased lipid peroxidation is related to muscle fibre atrophy, and reduced serum levels of some antioxidants may be related to loss of muscle mass and muscle strength. Finally, ethanol induces skeletal muscle apoptosis and increases both pro- and antiapoptotic regulatory mechanisms.
Citation:
Fernandez-Solà, J., Preedy, V.R., Lang, C.H., Gonzalez-Reimers, E., Arno, M., Lin, J.C.I., Wiseman, H., Zhou, S., Emery, P.W., Nakahara, T., Hashimoto, K., Hirano, M., Santolaria-Fernandez, F., Gonzalez-Hernandez, T., Fatjo, F., Sacanella, E., Estruch, R., Nicolas, J.M., Urbano-Marquez and A. (2007) 'Molecular and cellular events in alcohol-induced muscle disease', Alcoholism, Clinical and Experimental Research, 31(12), pp.1953-1962.
Publisher:
Wiley-Blackwell
Journal:
Alcoholism, clinical and experimental research
Issue Date:
Dec-2007
URI:
http://hdl.handle.net/10547/294843
DOI:
10.1111/j.1530-0277.2007.00530.x
PubMed ID:
18034690
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/18034690
Type:
Article
Language:
en
ISSN:
1530-0277
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorFernandez-Solà, Joaquimen_GB
dc.contributor.authorPreedy, Victor R.en_GB
dc.contributor.authorLang, Charles H.en_GB
dc.contributor.authorGonzalez-Reimers, Emilioen_GB
dc.contributor.authorArno, Matthewen_GB
dc.contributor.authorLin, J.C.I.en_GB
dc.contributor.authorWiseman, H.en_GB
dc.contributor.authorZhou, Shaoboen_GB
dc.contributor.authorEmery, P.W.en_GB
dc.contributor.authorNakahara, T.en_GB
dc.contributor.authorHashimoto, K.en_GB
dc.contributor.authorHirano, M.en_GB
dc.contributor.authorSantolaria-Fernández, F.en_GB
dc.contributor.authorGonzález-Hernández, T.en_GB
dc.contributor.authorFatjó, Francescen_GB
dc.contributor.authorSacanella, Emilioen_GB
dc.contributor.authorEstruch, Ramónen_GB
dc.contributor.authorNicolás, José M.en_GB
dc.contributor.authorUrbano-Márquez, Alvaroen_GB
dc.date.accessioned2013-06-28T08:46:13Zen
dc.date.available2013-06-28T08:46:13Zen
dc.date.issued2007-12en
dc.identifier.citationFernandez-Solà, J., Preedy, V.R., Lang, C.H., Gonzalez-Reimers, E., Arno, M., Lin, J.C.I., Wiseman, H., Zhou, S., Emery, P.W., Nakahara, T., Hashimoto, K., Hirano, M., Santolaria-Fernandez, F., Gonzalez-Hernandez, T., Fatjo, F., Sacanella, E., Estruch, R., Nicolas, J.M., Urbano-Marquez and A. (2007) 'Molecular and cellular events in alcohol-induced muscle disease', Alcoholism, Clinical and Experimental Research, 31(12), pp.1953-1962.en_GB
dc.identifier.issn1530-0277en
dc.identifier.pmid18034690en
dc.identifier.doi10.1111/j.1530-0277.2007.00530.xen
dc.identifier.urihttp://hdl.handle.net/10547/294843en
dc.description.abstractAlcohol consumption induces a dose-dependent noxious effect on skeletal muscle, leading to progressive functional and structural damage of myocytes, with concomitant reductions in lean body mass. Nearly half of high-dose chronic alcohol consumers develop alcoholic skeletal myopathy. The pathogenic mechanisms that lie between alcohol intake and loss of muscle tissue involve multiple pathways, making the elucidation of the disease somewhat difficult. This review discusses the recent advances in basic and clinical research on the molecular and cellular events involved in the development of alcohol-induced muscle disease. The main areas of recent research interest on this field are as follows: (i) molecular mechanisms in alcohol exposed muscle in the rat model; (ii) gene expression changes in alcohol exposed muscle; (iii) the role of trace elements and oxidative stress in alcoholic myopathy; and (iv) the role of apoptosis and preapoptotic pathways in alcoholic myopathy. These aforementioned areas are crucial in understanding the pathogenesis of this disease. For example, there is overwhelming evidence that both chronic alcohol ingestion and acute alcohol intoxication impair the rate of protein synthesis of myofibrillar proteins, in particular, under both postabsorptive and postprandial conditions. Perturbations in gene expression are contributory factors to the development of alcoholic myopathy, as ethanol-induced alterations are detected in over 400 genes and the protein profile (i.e., the proteome) of muscle is also affected. There is supportive evidence that oxidative damage is involved in the pathogenesis of alcoholic myopathy. Increased lipid peroxidation is related to muscle fibre atrophy, and reduced serum levels of some antioxidants may be related to loss of muscle mass and muscle strength. Finally, ethanol induces skeletal muscle apoptosis and increases both pro- and antiapoptotic regulatory mechanisms.en_GB
dc.language.isoenen
dc.publisherWiley-Blackwellen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18034690en_GB
dc.rightsArchived with thanks to Alcoholism, clinical and experimental researchen_GB
dc.subject.meshAlcohol-Induced Disordersen
dc.subject.meshAlcoholic Intoxicationen
dc.subject.meshAlcoholismen
dc.subject.meshAnimalsen
dc.subject.meshApoptosisen
dc.subject.meshGene Expressionen
dc.subject.meshHumansen
dc.subject.meshLipid Peroxidationen
dc.subject.meshMuscle Proteinsen
dc.subject.meshMuscle Weaknessen
dc.subject.meshMuscle, Skeletalen
dc.subject.meshMuscular Atrophyen
dc.subject.meshMuscular Diseasesen
dc.subject.meshOxidative Stressen
dc.subject.meshProteomeen
dc.subject.meshRatsen
dc.subject.meshTrace Elementsen
dc.titleMolecular and cellular events in alcohol-induced muscle diseaseen
dc.typeArticleen
dc.identifier.journalAlcoholism, clinical and experimental researchen_GB

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