2.50
Hdl Handle:
http://hdl.handle.net/10547/294842
Title:
Increased collagen synthesis rate during wound healing in muscle
Authors:
Zhou, Shaobo; Salisbury, Jonathan; Preedy, Victor R.; Emery, Peter W.; Roy, Sudipto
Abstract:
Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.
Citation:
Zhou, S., Salisbury, J., Preedy, V.R., Emery, P.W.,and Roy, S.(2013) 'Increased collagen synthesis rate during wound healing in muscle', PLoS ONE, 8(3),e58324.
Publisher:
Public Library of Science
Journal:
PLoS ONE
Issue Date:
2013
URI:
http://hdl.handle.net/10547/294842
DOI:
10.1371/journal.pone.0058324
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0058324
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorZhou, Shaoboen_GB
dc.contributor.authorSalisbury, Jonathanen_GB
dc.contributor.authorPreedy, Victor R.en_GB
dc.contributor.authorEmery, Peter W.en_GB
dc.contributor.authorRoy, Sudiptoen_GB
dc.date.accessioned2013-06-28T08:31:02Zen
dc.date.available2013-06-28T08:31:02Zen
dc.date.issued2013en
dc.identifier.citationZhou, S., Salisbury, J., Preedy, V.R., Emery, P.W.,and Roy, S.(2013) 'Increased collagen synthesis rate during wound healing in muscle', PLoS ONE, 8(3),e58324.en_GB
dc.identifier.issn1932-6203en
dc.identifier.doi10.1371/journal.pone.0058324en
dc.identifier.urihttp://hdl.handle.net/10547/294842en
dc.description.abstractWound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.en_GB
dc.language.isoenen
dc.publisherPublic Library of Scienceen_GB
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0058324en_GB
dc.rightsArchived with thanks to PLoS ONEen_GB
dc.subjectcollagen synthesisen_GB
dc.subjectwound healingen_GB
dc.subjectmuscleen_GB
dc.titleIncreased collagen synthesis rate during wound healing in muscleen
dc.typeArticleen
dc.identifier.journalPLoS ONEen_GB
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