Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl-substituted juvenile hormones

2.50
Hdl Handle:
http://hdl.handle.net/10547/294529
Title:
Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl-substituted juvenile hormones
Authors:
Cusson, Michel; Béliveau, Catherine; Sen, Stephanie E.; Vandermoten, Sophie; Rutledge, Robert G.; Stewart, Don; Francis, Frédéric; Haubruge, Éric; Rehse, Peter; Huggins, David J.; Dowling, Ashley P.G.; Grant, Guy H.
Abstract:
The sesquiterpenoid juvenile hormone (JH) regulates insect development and reproduction. Most insects produce only one chemical form of JH, but the Lepidoptera produce four derivatives featuring ethyl branches. The biogenesis of these JHs requires the synthesis of ethyl-substituted farnesyl diphosphate (FPP) by FPP synthase (FPPS). To determine if there exist more than one lepidopteran FPPS, and whether one FPPS homolog is better adapted for binding the bulkier ethyl-branched substrates/products, we cloned three lepidopteran FPPS cDNAs, two from Choristoneura fumiferana and one from Pseudaletia unipuncta. Amino acid sequence comparisons among these and other eukaryotic FPPSs led to the recognition of two lepidopteran FPPS types.
Citation:
Cusson, M., Béliveau, C., Sen, S.E., Vandermoten, S., Rutledge, R.G., Stewart, D., Francis, F., Haubruge, E., Rehse, P., Huggins, D.J., Dowling, A.P.G. and Grant, G.H. (2006) 'Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones', Proteins: Structure, Function, and Bioinformatics, 65(3), pp.742-758.
Publisher:
Wiley
Journal:
Proteins: Structure, Function, and Bioinformatics
Issue Date:
2006
URI:
http://hdl.handle.net/10547/294529
DOI:
10.1002/prot.21057
Additional Links:
http://doi.wiley.com/10.1002/prot.21057
Type:
Article
Language:
en
ISSN:
0887-3585; 1097-0134
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorCusson, Michelen_GB
dc.contributor.authorBéliveau, Catherineen_GB
dc.contributor.authorSen, Stephanie E.en_GB
dc.contributor.authorVandermoten, Sophieen_GB
dc.contributor.authorRutledge, Robert G.en_GB
dc.contributor.authorStewart, Donen_GB
dc.contributor.authorFrancis, Frédéricen_GB
dc.contributor.authorHaubruge, Éricen_GB
dc.contributor.authorRehse, Peteren_GB
dc.contributor.authorHuggins, David J.en_GB
dc.contributor.authorDowling, Ashley P.G.en_GB
dc.contributor.authorGrant, Guy H.en_GB
dc.date.accessioned2013-06-25T15:13:58Z-
dc.date.available2013-06-25T15:13:58Z-
dc.date.issued2006-
dc.identifier.citationCusson, M., Béliveau, C., Sen, S.E., Vandermoten, S., Rutledge, R.G., Stewart, D., Francis, F., Haubruge, E., Rehse, P., Huggins, D.J., Dowling, A.P.G. and Grant, G.H. (2006) 'Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones', Proteins: Structure, Function, and Bioinformatics, 65(3), pp.742-758.en_GB
dc.identifier.issn0887-3585-
dc.identifier.issn1097-0134-
dc.identifier.doi10.1002/prot.21057-
dc.identifier.urihttp://hdl.handle.net/10547/294529-
dc.description.abstractThe sesquiterpenoid juvenile hormone (JH) regulates insect development and reproduction. Most insects produce only one chemical form of JH, but the Lepidoptera produce four derivatives featuring ethyl branches. The biogenesis of these JHs requires the synthesis of ethyl-substituted farnesyl diphosphate (FPP) by FPP synthase (FPPS). To determine if there exist more than one lepidopteran FPPS, and whether one FPPS homolog is better adapted for binding the bulkier ethyl-branched substrates/products, we cloned three lepidopteran FPPS cDNAs, two from Choristoneura fumiferana and one from Pseudaletia unipuncta. Amino acid sequence comparisons among these and other eukaryotic FPPSs led to the recognition of two lepidopteran FPPS types.en_GB
dc.language.isoenen
dc.publisherWileyen_GB
dc.relation.urlhttp://doi.wiley.com/10.1002/prot.21057en_GB
dc.rightsArchived with thanks to Proteins: Structure, Function, and Bioinformaticsen_GB
dc.subjectJH homologsen_GB
dc.subjectmevalonate pathwayen_GB
dc.subjectgene structureen_GB
dc.subjecthomology modelingen_GB
dc.subjectdockingen_GB
dc.titleCharacterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl-substituted juvenile hormonesen
dc.typeArticleen
dc.identifier.journalProteins: Structure, Function, and Bioinformaticsen_GB
All Items in UOBREP are protected by copyright, with all rights reserved, unless otherwise indicated.