Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl-substituted juvenile hormones
Authors
Cusson, MichelBéliveau, Catherine
Sen, Stephanie E.
Vandermoten, Sophie
Rutledge, Robert G.
Stewart, Don
Francis, Frédéric
Haubruge, Éric
Rehse, Peter
Huggins, David J.
Dowling, Ashley P.G.
Grant, Guy H.
Issue Date
2006
Metadata
Show full item recordAbstract
The sesquiterpenoid juvenile hormone (JH) regulates insect development and reproduction. Most insects produce only one chemical form of JH, but the Lepidoptera produce four derivatives featuring ethyl branches. The biogenesis of these JHs requires the synthesis of ethyl-substituted farnesyl diphosphate (FPP) by FPP synthase (FPPS). To determine if there exist more than one lepidopteran FPPS, and whether one FPPS homolog is better adapted for binding the bulkier ethyl-branched substrates/products, we cloned three lepidopteran FPPS cDNAs, two from Choristoneura fumiferana and one from Pseudaletia unipuncta. Amino acid sequence comparisons among these and other eukaryotic FPPSs led to the recognition of two lepidopteran FPPS types.Citation
Cusson, M., Béliveau, C., Sen, S.E., Vandermoten, S., Rutledge, R.G., Stewart, D., Francis, F., Haubruge, E., Rehse, P., Huggins, D.J., Dowling, A.P.G. and Grant, G.H. (2006) 'Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones', Proteins: Structure, Function, and Bioinformatics, 65(3), pp.742-758.Publisher
WileyAdditional Links
http://doi.wiley.com/10.1002/prot.21057Type
ArticleLanguage
enISSN
0887-35851097-0134
ae974a485f413a2113503eed53cd6c53
10.1002/prot.21057