Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation.

2.50
Hdl Handle:
http://hdl.handle.net/10547/294526
Title:
Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation.
Authors:
Dubos, Christian; Willment, Janet; Huggins, David; Grant, Guy H.; Campbell, Malcolm M.
Abstract:
Ionotropic glutamate receptors (iGluRs) play important roles in neurotransmission in animals. There is growing evidence that iGluRs also play important roles in plants. Using a chemical genetics approach, which combined a pH-homeostasis mutant of Arabidopsis thaliana (de-etiolated3), several different iGluR agonists, molecular modelling, and reporter gene expression in transgenic plants, we provide evidence that iGluR agonism can induce dramatic changes in plant development and metabolism. Systematic hypothesis testing revealed a signalling circuit that integrates amino acid and sugar signals to affect elongation growth and the deposition of carbon into starch and lignins. The data show that aminoglycoside antibiotics, such as kanamycin, and polyamines impinge upon this circuit. These findings provide a mechanism for the conversion of amino acid and sugar signals into an appropriate response at the gene expression level, and underline the similarities in iGluR agonism between animals and plants.
Citation:
Dubos, C., Willment, J., Huggins, D., Grant, G.H. and Campbell, M.M. (2005) 'Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation', Plant Journal, 43(3),pp.348-355.
Publisher:
Wiley-Blackwell
Journal:
Plant Journal
Issue Date:
Aug-2005
URI:
http://hdl.handle.net/10547/294526
DOI:
10.1111/j.1365-313X.2005.02458.x
PubMed ID:
16045471
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/16045471
Type:
Article
Language:
en
ISSN:
0960-7412
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorDubos, Christianen_GB
dc.contributor.authorWillment, Janeten_GB
dc.contributor.authorHuggins, Daviden_GB
dc.contributor.authorGrant, Guy H.en_GB
dc.contributor.authorCampbell, Malcolm M.en_GB
dc.date.accessioned2013-06-25T14:57:05Z-
dc.date.available2013-06-25T14:57:05Z-
dc.date.issued2005-08-
dc.identifier.citationDubos, C., Willment, J., Huggins, D., Grant, G.H. and Campbell, M.M. (2005) 'Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation', Plant Journal, 43(3),pp.348-355.en_GB
dc.identifier.issn0960-7412-
dc.identifier.pmid16045471-
dc.identifier.doi10.1111/j.1365-313X.2005.02458.x-
dc.identifier.urihttp://hdl.handle.net/10547/294526-
dc.description.abstractIonotropic glutamate receptors (iGluRs) play important roles in neurotransmission in animals. There is growing evidence that iGluRs also play important roles in plants. Using a chemical genetics approach, which combined a pH-homeostasis mutant of Arabidopsis thaliana (de-etiolated3), several different iGluR agonists, molecular modelling, and reporter gene expression in transgenic plants, we provide evidence that iGluR agonism can induce dramatic changes in plant development and metabolism. Systematic hypothesis testing revealed a signalling circuit that integrates amino acid and sugar signals to affect elongation growth and the deposition of carbon into starch and lignins. The data show that aminoglycoside antibiotics, such as kanamycin, and polyamines impinge upon this circuit. These findings provide a mechanism for the conversion of amino acid and sugar signals into an appropriate response at the gene expression level, and underline the similarities in iGluR agonism between animals and plants.en_GB
dc.language.isoenen
dc.publisherWiley-Blackwellen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16045471en_GB
dc.rightsArchived with thanks to The Plant journal : for cell and molecular biologyen_GB
dc.subject.meshAminoglycosides-
dc.subject.meshArabidopsis-
dc.subject.meshArabidopsis Proteins-
dc.subject.meshBinding Sites-
dc.subject.meshExcitatory Amino Acid Agonists-
dc.subject.meshGene Expression Regulation, Plant-
dc.subject.meshGenotype-
dc.subject.meshHydrogen-Ion Concentration-
dc.subject.meshHypocotyl-
dc.subject.meshKanamycin-
dc.subject.meshLincomycin-
dc.subject.meshModels, Biological-
dc.subject.meshMutation-
dc.subject.meshNalidixic Acid-
dc.subject.meshPhenotype-
dc.subject.meshPlants, Genetically Modified-
dc.subject.meshReceptors, Glutamate-
dc.subject.meshVacuolar Proton-Translocating ATPases-
dc.titleKanamycin reveals the role played by glutamate receptors in shaping plant resource allocation.en
dc.typeArticleen
dc.identifier.journalPlant Journalen_GB

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