Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.

2.50
Hdl Handle:
http://hdl.handle.net/10547/294523
Title:
Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.
Authors:
Gal, Annamaria; Sjöblom, T.; Fedorova, L.; Imreh, S.; Beug, Hartmut; Moustakas, A.
Abstract:
To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure.
Citation:
Gal, A., Sjöblom, T., Fedorova, L., Imreh, S., Beug, H. and Moustakas, A. (2008) 'Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis', 'Oncogene', 27(9),pp. 1218-1230.
Publisher:
Nature Publishing Group
Journal:
Oncogene
Issue Date:
21-Feb-2008
URI:
http://hdl.handle.net/10547/294523
DOI:
10.1038/sj.onc.1210741
PubMed ID:
17724470
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/17724470; http://www.nature.com/onc/journal/v27/n9/full/1210741a.html
Type:
Article
Language:
en
ISSN:
1476-5594
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorGal, Annamariaen_GB
dc.contributor.authorSjöblom, T.en_GB
dc.contributor.authorFedorova, L.en_GB
dc.contributor.authorImreh, S.en_GB
dc.contributor.authorBeug, Hartmuten_GB
dc.contributor.authorMoustakas, A.en_GB
dc.date.accessioned2013-06-25T14:35:56Zen
dc.date.available2013-06-25T14:35:56Zen
dc.date.issued2008-02-21en
dc.identifier.citationGal, A., Sjöblom, T., Fedorova, L., Imreh, S., Beug, H. and Moustakas, A. (2008) 'Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis', 'Oncogene', 27(9),pp. 1218-1230.en_GB
dc.identifier.issn1476-5594en
dc.identifier.pmid17724470en
dc.identifier.doi10.1038/sj.onc.1210741en
dc.identifier.urihttp://hdl.handle.net/10547/294523en
dc.description.abstractTo better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure.en_GB
dc.language.isoenen
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/17724470en_GB
dc.relation.urlhttp://www.nature.com/onc/journal/v27/n9/full/1210741a.htmlen
dc.subjectepithelial–mesenchymal transitionen_GB
dc.subjectmetastasisen_GB
dc.subjectSmaden_GB
dc.subject.meshAnimalsen
dc.subject.meshApoptosisen
dc.subject.meshCHO Cellsen
dc.subject.meshCell Culture Techniquesen
dc.subject.meshCell Lineen
dc.subject.meshCell Transformation, Neoplasticen
dc.subject.meshCricetinaeen
dc.subject.meshCricetulusen
dc.subject.meshEpithelial Cellsen
dc.subject.meshFemaleen
dc.subject.meshGenes, Tumor Suppressoren
dc.subject.meshMammary Glands, Animalen
dc.subject.meshMesodermen
dc.subject.meshMiceen
dc.subject.meshSignal Transductionen
dc.subject.meshSmad Proteinsen
dc.subject.meshTransforming Growth Factor betaen
dc.titleSustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.en
dc.typeArticleen
dc.identifier.journalOncogeneen_GB

Related articles on PubMed

All Items in UOBREP are protected by copyright, with all rights reserved, unless otherwise indicated.