ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.

2.50
Hdl Handle:
http://hdl.handle.net/10547/294520
Title:
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.
Authors:
Waerner, Thomas; Alacakaptan, Memetcan; Tamir, Ido; Oberauer, Rupert; Gal, Annamaria; Brabletz, Thomas; Schreiber, Martin; Jechlinger, Martin; Beug, Hartmut
Abstract:
Erk/MAPK and TGFbeta signaling cause epithelial to mesenchymal transition (EMT) and metastasis in mouse mammary epithelial cells (EpH4) transformed with oncogenic Ras (EpRas). In trials to unravel underlying mechanisms, expression profiling for EMT-specific genes identified a secreted interleukin-related protein (ILEI), upregulated exclusively at the translational level. Stable overexpression of ILEI in EpH4 and EpRas cells caused EMT, tumor growth, and metastasis, independent of TGFbeta-R signaling and enhanced by Bcl2. RNAi-mediated knockdown of ILEI in EpRas cells before and after EMT (EpRasXT) prevented and reverted TGFbeta-dependent EMT, also abrogating metastasis formation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
Citation:
Waerner, T., Alacakaptan, M., Tamir, I., Oberauer, R., Gal, A., Brabletz, T., Schreiber, M., Jechlinger, M., Beug, H. (2006) 'ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells', "Cancer Cell", 10(3),pp. 227-239.
Publisher:
Elsevier
Journal:
Cancer cell
Issue Date:
Sep-2006
URI:
http://hdl.handle.net/10547/294520
DOI:
10.1016/j.ccr.2006.07.020
PubMed ID:
16959614
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/16959614
Type:
Article
Language:
en
ISSN:
1535-6108
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorWaerner, Thomasen_GB
dc.contributor.authorAlacakaptan, Memetcanen_GB
dc.contributor.authorTamir, Idoen_GB
dc.contributor.authorOberauer, Ruperten_GB
dc.contributor.authorGal, Annamariaen_GB
dc.contributor.authorBrabletz, Thomasen_GB
dc.contributor.authorSchreiber, Martinen_GB
dc.contributor.authorJechlinger, Martinen_GB
dc.contributor.authorBeug, Hartmuten_GB
dc.date.accessioned2013-06-25T13:28:29Z-
dc.date.available2013-06-25T13:28:29Z-
dc.date.issued2006-09-
dc.identifier.citationWaerner, T., Alacakaptan, M., Tamir, I., Oberauer, R., Gal, A., Brabletz, T., Schreiber, M., Jechlinger, M., Beug, H. (2006) 'ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells', "Cancer Cell", 10(3),pp. 227-239.en_GB
dc.identifier.issn1535-6108-
dc.identifier.pmid16959614-
dc.identifier.doi10.1016/j.ccr.2006.07.020-
dc.identifier.urihttp://hdl.handle.net/10547/294520-
dc.description.abstractErk/MAPK and TGFbeta signaling cause epithelial to mesenchymal transition (EMT) and metastasis in mouse mammary epithelial cells (EpH4) transformed with oncogenic Ras (EpRas). In trials to unravel underlying mechanisms, expression profiling for EMT-specific genes identified a secreted interleukin-related protein (ILEI), upregulated exclusively at the translational level. Stable overexpression of ILEI in EpH4 and EpRas cells caused EMT, tumor growth, and metastasis, independent of TGFbeta-R signaling and enhanced by Bcl2. RNAi-mediated knockdown of ILEI in EpRas cells before and after EMT (EpRasXT) prevented and reverted TGFbeta-dependent EMT, also abrogating metastasis formation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.en_GB
dc.language.isoenen
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16959614en_GB
dc.rightsArchived with thanks to Cancer cellen_GB
dc.subjectCellbioen_GB
dc.subject.meshAnimals-
dc.subject.meshCell Differentiation-
dc.subject.meshCell Line-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshCytokines-
dc.subject.meshEpithelial Cells-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshHumans-
dc.subject.meshMesenchymal Stromal Cells-
dc.subject.meshMice-
dc.subject.meshMice, Inbred BALB C-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshNeoplasm Transplantation-
dc.subject.meshNeoplasms-
dc.subject.meshPrognosis-
dc.subject.meshProtein Biosynthesis-
dc.subject.meshRNA Interference-
dc.subject.meshRNA, Messenger-
dc.subject.meshSignal Transduction-
dc.subject.meshSurvival Rate-
dc.subject.meshTime Factors-
dc.subject.meshTransforming Growth Factor beta-
dc.titleILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.en
dc.typeArticleen
dc.identifier.journalCancer cellen_GB

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