2.50
Hdl Handle:
http://hdl.handle.net/10547/294498
Title:
Tetraspanin in oncogenic epithelial-mesenchymal transition
Authors:
Muschel, Ruth J.; Gal, Annamaria
Abstract:
Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpression of the tetraspanin superfamily member TM4SF5 in human hepatocellular carcinoma cells causes cellular phenotypic changes that resemble classical descriptions of epithelial-mesenchymal transition (EMT), with some unique aspects. They also show that these TM4SF5-mediated effects trigger tumor formation when these cells are injected into mice. The study implicates TM4SF5, for the first time to our knowledge, in EMT oncogenic pathways of cancer progression.
Citation:
Muschel, R.J. and Gal, A. (2008) 'Tetraspanin in oncogenic epithelial-mesenchymal transition', Journal of Clinical Investigation, 118 (4),pp.1347-1350.
Publisher:
American Society for Clinical Investigation
Journal:
Journal of Clinical Investigation
Issue Date:
2008
URI:
http://hdl.handle.net/10547/294498
DOI:
10.1172/JCI35308
Additional Links:
http://www.jci.org/articles/view/35308
Type:
Article
Language:
en
ISSN:
0021-9738
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorMuschel, Ruth J.en_GB
dc.contributor.authorGal, Annamariaen_GB
dc.date.accessioned2013-06-25T13:17:33Z-
dc.date.available2013-06-25T13:17:33Z-
dc.date.issued2008-
dc.identifier.citationMuschel, R.J. and Gal, A. (2008) 'Tetraspanin in oncogenic epithelial-mesenchymal transition', Journal of Clinical Investigation, 118 (4),pp.1347-1350.en_GB
dc.identifier.issn0021-9738-
dc.identifier.doi10.1172/JCI35308-
dc.identifier.urihttp://hdl.handle.net/10547/294498-
dc.description.abstractMembers of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpression of the tetraspanin superfamily member TM4SF5 in human hepatocellular carcinoma cells causes cellular phenotypic changes that resemble classical descriptions of epithelial-mesenchymal transition (EMT), with some unique aspects. They also show that these TM4SF5-mediated effects trigger tumor formation when these cells are injected into mice. The study implicates TM4SF5, for the first time to our knowledge, in EMT oncogenic pathways of cancer progression.en_GB
dc.language.isoenen
dc.publisherAmerican Society for Clinical Investigationen_GB
dc.relation.urlhttp://www.jci.org/articles/view/35308en_GB
dc.rightsArchived with thanks to Journal of Clinical Investigationen_GB
dc.subjectcarcinomaen_GB
dc.subjecthepatocellularen_GB
dc.subjectcell differentiationen_GB
dc.subjectepithelial cellsen_GB
dc.subjectmembrane proteinsen_GB
dc.titleTetraspanin in oncogenic epithelial-mesenchymal transitionen
dc.typeArticleen
dc.identifier.journalJournal of Clinical Investigationen_GB
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