Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus Mutans

2.50
Hdl Handle:
http://hdl.handle.net/10547/293985
Title:
Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus Mutans
Authors:
Allan, Elaine; Hussain, Haitham A.; Crawford, Kevin R.; Miah, Shahjahan; Ascott, Zoë K.; Khwaja, Mahrukh H.; Hosie, Arthur H.F. ( 0000-0002-1327-7901 )
Abstract:
The genetic variability in comC, the gene encoding the quorum-sensing molecule, competence-stimulating peptide (CSP) in Streptococcus mutans is reported. Seven comC alleles encoding three distinct mature CSPs were identified among 36 geographically diverse strains, although, compared with Streptococcus pneumoniae, the amount of predicted amino acid sequence variation is low. In agreement with other studies, significant variation was found in the natural competence for DNA uptake in these strains. However, there was no correlation between the CSP genotype and the ability to transform these strains. Representative strains encoding each of the CSP variants became competent in response to synthetic CSPs of each type. Therefore, in contrast to S. pneumoniae, comC alleles in S. mutans are functionally equivalent and there is no evidence of pherotype specificity.
Citation:
Allan, E., Hussain, H.A., Crawford, K.R., Miah, S., Ascott, Z.K., Khwaja, M.H. and Hosie, A.H.F. (2007) 'Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus Mutans', FEMS Microbiology Letters, 268(1),pp.47-51
Publisher:
Blackwell Publishing
Journal:
FEMS Microbiology Letters
Issue Date:
2007
URI:
http://hdl.handle.net/10547/293985
DOI:
10.1111/j.1574-6968.2006.00593.x
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/17229063
Type:
Article
Language:
en
ISSN:
0378-1097; 1574-6968
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorAllan, Elaineen_GB
dc.contributor.authorHussain, Haitham A.en_GB
dc.contributor.authorCrawford, Kevin R.en_GB
dc.contributor.authorMiah, Shahjahanen_GB
dc.contributor.authorAscott, Zoë K.en_GB
dc.contributor.authorKhwaja, Mahrukh H.en_GB
dc.contributor.authorHosie, Arthur H.F.en_GB
dc.date.accessioned2013-06-14T13:17:05Z-
dc.date.available2013-06-14T13:17:05Z-
dc.date.issued2007-
dc.identifier.citationAllan, E., Hussain, H.A., Crawford, K.R., Miah, S., Ascott, Z.K., Khwaja, M.H. and Hosie, A.H.F. (2007) 'Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus Mutans', FEMS Microbiology Letters, 268(1),pp.47-51en_GB
dc.identifier.issn0378-1097-
dc.identifier.issn1574-6968-
dc.identifier.doi10.1111/j.1574-6968.2006.00593.x-
dc.identifier.urihttp://hdl.handle.net/10547/293985-
dc.description.abstractThe genetic variability in comC, the gene encoding the quorum-sensing molecule, competence-stimulating peptide (CSP) in Streptococcus mutans is reported. Seven comC alleles encoding three distinct mature CSPs were identified among 36 geographically diverse strains, although, compared with Streptococcus pneumoniae, the amount of predicted amino acid sequence variation is low. In agreement with other studies, significant variation was found in the natural competence for DNA uptake in these strains. However, there was no correlation between the CSP genotype and the ability to transform these strains. Representative strains encoding each of the CSP variants became competent in response to synthetic CSPs of each type. Therefore, in contrast to S. pneumoniae, comC alleles in S. mutans are functionally equivalent and there is no evidence of pherotype specificity.en_GB
dc.language.isoenen
dc.publisherBlackwell Publishingen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/17229063en_GB
dc.rightsArchived with thanks to FEMS Microbiology Lettersen_GB
dc.subjectStreptococcus mutansen_GB
dc.subjectcompetence stimulating peptideen_GB
dc.subjectgenetic competenceen_GB
dc.subjectnatural transformationen_GB
dc.subjectGenetic diversityen_GB
dc.titleGenetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus Mutansen
dc.typeArticleen
dc.identifier.journalFEMS Microbiology Lettersen_GB
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