Rhizobium leguminosarum has a second general amino acid permease with unusually broad substrate specificity and high similarity to branched-chain amino acid transporters (Bra/LIV) of the ABC family

2.50
Hdl Handle:
http://hdl.handle.net/10547/293975
Title:
Rhizobium leguminosarum has a second general amino acid permease with unusually broad substrate specificity and high similarity to branched-chain amino acid transporters (Bra/LIV) of the ABC family
Authors:
Hosie, Arthur H.F. ( 0000-0002-1327-7901 ) ; Allaway, D.; Galloway, C.S.; Dunsby, H.A.; Poole, Philip S.
Abstract:
Amino acid uptake by Rhizobium leguminosarum is dominated by two ABC transporters, the general amino acid permease (Aap) and the branched-chain amino acid permease (BraRl). Characterization of the solute specificity of BraRl shows it to be the second general amino acid permease of R. leguminosarum. Although BraRl has high sequence identity to members of the family of hydrophobic amino acid transporters (HAAT), it transports a broad range of solutes, including acidic and basic polar amino acids (l-glutamate, l-arginine, and l-histidine), in addition to neutral amino acids (l-alanine and l-leucine). Overall, the data indicate that BraRl is a general amino acid permease of the HAAT family. Furthermore, BraRl has the broadest solute specificity of any characterized bacterial amino acid transporter.
Affiliation:
School of Animal and Microbial Sciences, University of Reading
Citation:
Hosie, A. H.F., Allaway, D., Galloway, C. S., Dunsby, H.A. and Poole, P.S. (2002) 'Rhizobium Leguminosarum has a second general amino acid permease with unusually broad substrate specificity and high similarity to branched-chain amino acid transporters (Bra/LIV) of the ABC Family', Journal of Bacteriology, 184(15), pp.4071-4080
Publisher:
American Society for Microbiology
Journal:
Journal of Bacteriology
Issue Date:
2002
URI:
http://hdl.handle.net/10547/293975
DOI:
10.1128/JB.184.15.4071-4080.2002
Additional Links:
http://jb.asm.org/cgi/doi/10.1128/JB.184.15.4071-4080.2002
Type:
Article
Language:
en
ISSN:
0021-9193
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorHosie, Arthur H.F.en_GB
dc.contributor.authorAllaway, D.en_GB
dc.contributor.authorGalloway, C.S.en_GB
dc.contributor.authorDunsby, H.A.en_GB
dc.contributor.authorPoole, Philip S.en_GB
dc.date.accessioned2013-06-14T12:39:36Z-
dc.date.available2013-06-14T12:39:36Z-
dc.date.issued2002-
dc.identifier.citationHosie, A. H.F., Allaway, D., Galloway, C. S., Dunsby, H.A. and Poole, P.S. (2002) 'Rhizobium Leguminosarum has a second general amino acid permease with unusually broad substrate specificity and high similarity to branched-chain amino acid transporters (Bra/LIV) of the ABC Family', Journal of Bacteriology, 184(15), pp.4071-4080en_GB
dc.identifier.issn0021-9193-
dc.identifier.doi10.1128/JB.184.15.4071-4080.2002-
dc.identifier.urihttp://hdl.handle.net/10547/293975-
dc.description.abstractAmino acid uptake by Rhizobium leguminosarum is dominated by two ABC transporters, the general amino acid permease (Aap) and the branched-chain amino acid permease (BraRl). Characterization of the solute specificity of BraRl shows it to be the second general amino acid permease of R. leguminosarum. Although BraRl has high sequence identity to members of the family of hydrophobic amino acid transporters (HAAT), it transports a broad range of solutes, including acidic and basic polar amino acids (l-glutamate, l-arginine, and l-histidine), in addition to neutral amino acids (l-alanine and l-leucine). Overall, the data indicate that BraRl is a general amino acid permease of the HAAT family. Furthermore, BraRl has the broadest solute specificity of any characterized bacterial amino acid transporter.en_GB
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen_GB
dc.relation.urlhttp://jb.asm.org/cgi/doi/10.1128/JB.184.15.4071-4080.2002en_GB
dc.rightsArchived with thanks to Journal of Bacteriologyen_GB
dc.subjectABC transporteren_GB
dc.subjectrhizobiumen_GB
dc.subjectamino acid permeaseen_GB
dc.titleRhizobium leguminosarum has a second general amino acid permease with unusually broad substrate specificity and high similarity to branched-chain amino acid transporters (Bra/LIV) of the ABC familyen
dc.typeArticleen
dc.contributor.departmentSchool of Animal and Microbial Sciences, University of Readingen_GB
dc.identifier.journalJournal of Bacteriologyen_GB
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