Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling

2.50
Hdl Handle:
http://hdl.handle.net/10547/250973
Title:
Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling
Authors:
van Eijl, Sven; Zhu, Zheying; Cupitt, John; Gierula, Magdalena ( 0000-0002-8450-696X ) ; Götz, Christine; Fritsche, Ellen; Edwards, Robert J.; Rodrigues-Lima, Fernando
Abstract:
Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present in human skin and hence indicate principal routes of metabolism of xenobiotic compounds. Several in vitro models of human skin have been developed for the purpose of safety assessment of chemicals. The suitability of these epidermal models for studies involving biotransformation was assessed by comparing their profiles of xenobiotic metabolising enzymes with those of human skin.
Citation:
Van Eijl, S., Zhu, Z., Cupitt, J., Gierula, M., Gotz, C., Fritsche, E., Edwards, R.J., and Rodrigues-Lima, F. (2012) "Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling", "PLOS One" [Online] 7 (7). Available at: http://dx.plos.org/10.1371/journal.pone.0041721
Publisher:
Public Library of Science
Journal:
PLOS One
Issue Date:
26-Jul-2012
URI:
http://hdl.handle.net/10547/250973
DOI:
10.1371/journal.pone.0041721
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0041721
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorvan Eijl, Svenen_GB
dc.contributor.authorZhu, Zheyingen_GB
dc.contributor.authorCupitt, Johnen_GB
dc.contributor.authorGierula, Magdalenaen_GB
dc.contributor.authorGötz, Christineen_GB
dc.contributor.authorFritsche, Ellenen_GB
dc.contributor.authorEdwards, Robert J.en_GB
dc.contributor.authorRodrigues-Lima, Fernandoen_GB
dc.date.accessioned2012-11-05T12:14:46Z-
dc.date.available2012-11-05T12:14:46Z-
dc.date.issued2012-07-26-
dc.identifier.citationVan Eijl, S., Zhu, Z., Cupitt, J., Gierula, M., Gotz, C., Fritsche, E., Edwards, R.J., and Rodrigues-Lima, F. (2012) "Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling", "PLOS One" [Online] 7 (7). Available at: http://dx.plos.org/10.1371/journal.pone.0041721en_GB
dc.identifier.issn1932-6203-
dc.identifier.doi10.1371/journal.pone.0041721-
dc.identifier.urihttp://hdl.handle.net/10547/250973-
dc.description.abstractHuman skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present in human skin and hence indicate principal routes of metabolism of xenobiotic compounds. Several in vitro models of human skin have been developed for the purpose of safety assessment of chemicals. The suitability of these epidermal models for studies involving biotransformation was assessed by comparing their profiles of xenobiotic metabolising enzymes with those of human skin.en_GB
dc.language.isoenen
dc.publisherPublic Library of Scienceen_GB
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0041721en_GB
dc.rightsArchived with thanks to PLoS ONEen_GB
dc.subjectproteomics profilingen_GB
dc.subjectxenobioticsen_GB
dc.subjectproteomicsen_GB
dc.subjectskinen_GB
dc.subjectepidermal modelsen_GB
dc.subjectbiotransformationen_GB
dc.titleElucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profilingen
dc.typeArticleen
dc.identifier.journalPLOS Oneen_GB
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