2.50
Hdl Handle:
http://hdl.handle.net/10547/229051
Title:
Targeting locoregional peritoneal dissemination in ovarian cancer
Authors:
Janczar, Szymon; Graham, Janet S.; Paige, Adam J.W.; Gabra, Hani
Abstract:
Ovarian carcinoma is the most lethal of the gynecological malignancies. This cancer is characterized by a high frequency of peritoneal dissemination resulting in significant morbidity and mortality, a situation unlike many other cancers. Together with resistance to chemotherapy, this locoregional peritoneal dissemination appears to be the major challenge and obstacle to improving outcomes in ovarian cancer. Relatively little scientific effort has been invested in making significant progress in the latter; therefore, developing a sound understanding of the molecular events underlying that process would be helpful. The focus of this review is to discuss the research that has been undertaken preclinically and clinically to conceptually develop the principles of, understand and target locoregional peritoneal dissemination in ovarian cancer.
Citation:
Targeting locoregional peritoneal dissemination in ovarian cancer 2009, 4 (2):133-147 Expert Review of Obstetrics & Gynecology
Publisher:
Expert Reviews
Journal:
Expert Review of Obstetrics & Gynecology
Issue Date:
Mar-2009
URI:
http://hdl.handle.net/10547/229051
DOI:
10.1586/17474108.4.2.133
Additional Links:
http://www.expert-reviews.com/doi/abs/10.1586/17474108.4.2.133
Type:
Article
Language:
en
ISSN:
1747-4108; 1747-4116
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorJanczar, Szymonen_GB
dc.contributor.authorGraham, Janet S.en_GB
dc.contributor.authorPaige, Adam J.W.en_GB
dc.contributor.authorGabra, Hanien_GB
dc.date.accessioned2012-06-15T08:02:07Z-
dc.date.available2012-06-15T08:02:07Z-
dc.date.issued2009-03-
dc.identifier.citationTargeting locoregional peritoneal dissemination in ovarian cancer 2009, 4 (2):133-147 Expert Review of Obstetrics & Gynecologyen_GB
dc.identifier.issn1747-4108-
dc.identifier.issn1747-4116-
dc.identifier.doi10.1586/17474108.4.2.133-
dc.identifier.urihttp://hdl.handle.net/10547/229051-
dc.description.abstractOvarian carcinoma is the most lethal of the gynecological malignancies. This cancer is characterized by a high frequency of peritoneal dissemination resulting in significant morbidity and mortality, a situation unlike many other cancers. Together with resistance to chemotherapy, this locoregional peritoneal dissemination appears to be the major challenge and obstacle to improving outcomes in ovarian cancer. Relatively little scientific effort has been invested in making significant progress in the latter; therefore, developing a sound understanding of the molecular events underlying that process would be helpful. The focus of this review is to discuss the research that has been undertaken preclinically and clinically to conceptually develop the principles of, understand and target locoregional peritoneal dissemination in ovarian cancer.en_GB
dc.language.isoenen
dc.publisherExpert Reviewsen_GB
dc.relation.urlhttp://www.expert-reviews.com/doi/abs/10.1586/17474108.4.2.133en_GB
dc.rightsArchived with thanks to Expert Review of Obstetrics & Gynecologyen_GB
dc.subjectcadherinen_GB
dc.subjectchemotherapyen_GB
dc.subjectextracellular matrixen_GB
dc.subjectintegrinen_GB
dc.subjectmetastasisen_GB
dc.subjectovarian canceren_GB
dc.subjectperitoneal disseminationen_GB
dc.titleTargeting locoregional peritoneal dissemination in ovarian canceren
dc.typeArticleen
dc.identifier.journalExpert Review of Obstetrics & Gynecologyen_GB
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