Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis.

2.50
Hdl Handle:
http://hdl.handle.net/10547/228739
Title:
Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis.
Authors:
Reynolds, John
Abstract:
Goodpasture's, or anti-glomerular basement membrane (GBM), disease presents with rapidly progressive glomerulonephritis, caused by autoimmunity to a component of the GBM, the non-collagenous domain of the α3 chain of type IV collagen [α3(IV)NC1]. To investigate the mechanisms of inflammation in glomerulonephritis and to test new approaches to treatment, animal models of glomerulonephritis, termed experimental autoimmune glomerulonephritis (EAG), have been developed in susceptible strains of rats and mice. This review article describes how these models of EAG have been developed over the past three decades, discusses the evidence for the involvement of both humoral and cell-mediated immunity in the induction and pathogenesis of glomerulonephritis in these models and highlights recent, emerging data that have identified potential candidate genes that may control the genetic susceptibility in these different strains of rats and mice. The identification of these susceptibility genes has lead to a better understanding of the genetic basis of this model of anti-GBM disease, which may be relevant to the immunopathogenesis of Goodpasture's disease, and more generally to the progression from autoimmunity to target-organ damage.
Affiliation:
Division of Science, Park Square Campus, University of Bedfordshire, Luton, UK. john.reynolds@beds.ac.uk
Citation:
Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis. 2011, 92 (3):211-217 Int J Exp Pathol
Publisher:
Blackwell Publishing
Journal:
International journal of experimental pathology
Issue Date:
Jun-2011
URI:
http://hdl.handle.net/10547/228739
DOI:
10.1111/j.1365-2613.2011.00763.x
PubMed ID:
21342299
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/21342299
Type:
Article
Language:
en
ISSN:
1365-2613
Appears in Collections:
Cell and Cryobiology Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorReynolds, Johnen_GB
dc.date.accessioned2012-06-13T11:33:37Z-
dc.date.available2012-06-13T11:33:37Z-
dc.date.issued2011-06-
dc.identifier.citationStrain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis. 2011, 92 (3):211-217 Int J Exp Patholen_GB
dc.identifier.issn1365-2613-
dc.identifier.pmid21342299-
dc.identifier.doi10.1111/j.1365-2613.2011.00763.x-
dc.identifier.urihttp://hdl.handle.net/10547/228739-
dc.description.abstractGoodpasture's, or anti-glomerular basement membrane (GBM), disease presents with rapidly progressive glomerulonephritis, caused by autoimmunity to a component of the GBM, the non-collagenous domain of the α3 chain of type IV collagen [α3(IV)NC1]. To investigate the mechanisms of inflammation in glomerulonephritis and to test new approaches to treatment, animal models of glomerulonephritis, termed experimental autoimmune glomerulonephritis (EAG), have been developed in susceptible strains of rats and mice. This review article describes how these models of EAG have been developed over the past three decades, discusses the evidence for the involvement of both humoral and cell-mediated immunity in the induction and pathogenesis of glomerulonephritis in these models and highlights recent, emerging data that have identified potential candidate genes that may control the genetic susceptibility in these different strains of rats and mice. The identification of these susceptibility genes has lead to a better understanding of the genetic basis of this model of anti-GBM disease, which may be relevant to the immunopathogenesis of Goodpasture's disease, and more generally to the progression from autoimmunity to target-organ damage.en_GB
dc.language.isoenen
dc.publisherBlackwell Publishingen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21342299en_GB
dc.rightsArchived with thanks to International journal of experimental pathologyen_GB
dc.subject.meshAnimals-
dc.subject.meshAnti-Glomerular Basement Membrane Disease-
dc.subject.meshDisease Models, Animal-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshImmunity, Cellular-
dc.subject.meshImmunity, Humoral-
dc.subject.meshMice-
dc.subject.meshMice, Inbred AKR-
dc.subject.meshMice, Inbred C57BL-
dc.subject.meshMice, Inbred CBA-
dc.subject.meshMice, Inbred DBA-
dc.subject.meshRats-
dc.subject.meshRats, Inbred BN-
dc.subject.meshRats, Inbred F344-
dc.subject.meshRats, Inbred Lew-
dc.subject.meshRats, Inbred WKY-
dc.titleStrain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis.en
dc.typeArticleen
dc.contributor.departmentDivision of Science, Park Square Campus, University of Bedfordshire, Luton, UK. john.reynolds@beds.ac.uken_GB
dc.identifier.journalInternational journal of experimental pathologyen_GB

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