Selenium supplementation and exercise: effect on oxidant stress in overweight adults

2.50
Hdl Handle:
http://hdl.handle.net/10547/225637
Title:
Selenium supplementation and exercise: effect on oxidant stress in overweight adults
Authors:
Savory, Louise A.; Kerr, Catherine J.; Whiting, Paul; Finer, Nicholas; McEneny, Jane; Ashton, Tony
Abstract:
Both obesity and acute high-intensity exercise increase oxidant stress levels. This study investigates whether selenium (Se) supplementation could be a potential effective therapy to reduce obesity-associated oxidant stress and exercise-induced oxidant stress. Ten normal-weight (NW) (22.80 ± 0.41 kg/m(2)) and ten overweight (OW) healthy subjects (28.00 ± 0.81 kg/m(2)) were assessed during a randomized double-blind Se supplementation study (200 µg sodium selenite/day for 3 weeks) with a 3-week placebo control and inversion of treatment periods. Blood levels of lipid hydroperoxide (LH), superoxide dismutase (SOD), erythrocyte glutathione (GSH), and total antioxidant status (TAS), were measured at rest, pre-, and postexercise (30 min 70% VO(2) max before and after treatment (pretreatment (week 0 and 12) and post-treatment (week 3 or 15)). At rest, compared to placebo, Se supplementation had no significant effect on LH, SOD, GSH, and TAS levels. However, Se supplementation decreased LH levels in the OW group, immediately postexercise (-0.25 ± 0.12 µmol/l, P = 0.05) compared to placebo treatment. Postexercise, with or without Se supplementation, no changes in TAS, SOD, and GSH levels were observed in both the NW and OW group. This study has highlighted a potential benefit of Se in reducing LH levels postexercise in OW individuals. Given that oxidant stress is a predictor of coronary events, it is imperative to better understand oxidant stress-related responses to lifestyle factors (in particular "high-risk" population groups) and potential antioxidant therapy.
Affiliation:
Department of Sport and Exercise Sciences, University of Bedfordshire
Citation:
Savory, L.A., Kerr, C.J., Whiting, P., Finer, N., McEneny, J. and Ashton, T., (2012) 'Selenium supplementation and exercise: effect on oxidant stress in overweight adults', Obesity, 20(4) pp.794-801.
Publisher:
Wiley
Journal:
Obesity (Silver Spring, Md.)
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10547/225637
DOI:
10.1038/oby.2011.83; 10.1038/oby.2011.83
PubMed ID:
21593809
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.83/full
Type:
Article
Language:
en
ISSN:
1930-7381
Appears in Collections:
Physical Activity and Health

Full metadata record

DC FieldValue Language
dc.contributor.authorSavory, Louise A.en_GB
dc.contributor.authorKerr, Catherine J.en_GB
dc.contributor.authorWhiting, Paulen_GB
dc.contributor.authorFiner, Nicholasen_GB
dc.contributor.authorMcEneny, Janeen_GB
dc.contributor.authorAshton, Tonyen_GB
dc.date.accessioned2012-05-23T15:39:56Z-
dc.date.available2012-05-23T15:39:56Z-
dc.date.issued2012-04-
dc.identifier.citationSavory, L.A., Kerr, C.J., Whiting, P., Finer, N., McEneny, J. and Ashton, T., (2012) 'Selenium supplementation and exercise: effect on oxidant stress in overweight adults', Obesity, 20(4) pp.794-801.en_GB
dc.identifier.issn1930-7381-
dc.identifier.pmid21593809-
dc.identifier.doi10.1038/oby.2011.83-
dc.identifier.doi10.1038/oby.2011.83-
dc.identifier.urihttp://hdl.handle.net/10547/225637-
dc.description.abstractBoth obesity and acute high-intensity exercise increase oxidant stress levels. This study investigates whether selenium (Se) supplementation could be a potential effective therapy to reduce obesity-associated oxidant stress and exercise-induced oxidant stress. Ten normal-weight (NW) (22.80 ± 0.41 kg/m(2)) and ten overweight (OW) healthy subjects (28.00 ± 0.81 kg/m(2)) were assessed during a randomized double-blind Se supplementation study (200 µg sodium selenite/day for 3 weeks) with a 3-week placebo control and inversion of treatment periods. Blood levels of lipid hydroperoxide (LH), superoxide dismutase (SOD), erythrocyte glutathione (GSH), and total antioxidant status (TAS), were measured at rest, pre-, and postexercise (30 min 70% VO(2) max before and after treatment (pretreatment (week 0 and 12) and post-treatment (week 3 or 15)). At rest, compared to placebo, Se supplementation had no significant effect on LH, SOD, GSH, and TAS levels. However, Se supplementation decreased LH levels in the OW group, immediately postexercise (-0.25 ± 0.12 µmol/l, P = 0.05) compared to placebo treatment. Postexercise, with or without Se supplementation, no changes in TAS, SOD, and GSH levels were observed in both the NW and OW group. This study has highlighted a potential benefit of Se in reducing LH levels postexercise in OW individuals. Given that oxidant stress is a predictor of coronary events, it is imperative to better understand oxidant stress-related responses to lifestyle factors (in particular "high-risk" population groups) and potential antioxidant therapy.en_GB
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1038/oby.2011.83/full-
dc.rightsArchived with thanks to Obesity (Silver Spring, Md.)en_GB
dc.titleSelenium supplementation and exercise: effect on oxidant stress in overweight adultsen
dc.typeArticleen
dc.contributor.departmentDepartment of Sport and Exercise Sciences, University of Bedfordshireen_GB
dc.identifier.journalObesity (Silver Spring, Md.)en_GB

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