2.50
Hdl Handle:
http://hdl.handle.net/10547/224578
Title:
Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells.
Authors:
Greiner, Jochen; Bullinger, Lars; Guinn, Barbara-Ann; Döhner, Hartmut; Schmitt, Michael
Abstract:
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. With intensive induction therapy, most patients younger than 60 years achieve complete remission. However, even if these younger patients were treated intensively, more than 50% will relapse. Clinical results of patients older than 60 years are more unfavorable. Therefore, in all patients with AML, the overall survival is still low. In the past decade, several leukemia-associated antigens (LAA) have been identified in patients with acute myeloid leukemia. BAGE, BCL-2, OFA-iLRP, FLT3-ITD, G250, hTERT, PRAME, proteinase 3, RHAMM, survivin, and WT-1 are all LAAs that have been shown to induce CD8+ T-cell recognition and for some antigens also humoral immune responses. Interestingly, most of these LAAs are linked to cell cycle or proliferation. This article discusses the balance between LAA-driven leukemia cell expansion and the elimination of these cells through attacks on LAAs by the immune system. Current knowledge of the function and CD8+ T-cell recognition of LAAs is reviewed and an outlook is given on how to improve T-cell responses to LAAs in acute myeloid leukemia cells.
Affiliation:
Department of Internal Medicine III, University of Ulm, Ulm, Germany. jochen.greiner@uniklinik-ulm.de
Citation:
Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells. 2008, 14 (22):7161-6 Clin. Cancer Res.
Publisher:
HighWire Press
Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Issue Date:
15-Nov-2008
URI:
http://hdl.handle.net/10547/224578
DOI:
10.1158/1078-0432.CCR-08-1102
PubMed ID:
19010831
Additional Links:
http://clincancerres.aacrjournals.org/content/14/22/7161.long
Type:
Article
Language:
en
ISSN:
1078-0432
Appears in Collections:
Biomedicine and Nutrition Research Group

Full metadata record

DC FieldValue Language
dc.contributor.authorGreiner, Jochenen_GB
dc.contributor.authorBullinger, Larsen_GB
dc.contributor.authorGuinn, Barbara-Annen_GB
dc.contributor.authorDöhner, Hartmuten_GB
dc.contributor.authorSchmitt, Michaelen_GB
dc.date.accessioned2012-05-18T10:39:02Z-
dc.date.available2012-05-18T10:39:02Z-
dc.date.issued2008-11-15-
dc.identifier.citationLeukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells. 2008, 14 (22):7161-6 Clin. Cancer Res.en_GB
dc.identifier.issn1078-0432-
dc.identifier.pmid19010831-
dc.identifier.doi10.1158/1078-0432.CCR-08-1102-
dc.identifier.urihttp://hdl.handle.net/10547/224578-
dc.description.abstractAcute myeloid leukemia (AML) is the most common acute leukemia in adults. With intensive induction therapy, most patients younger than 60 years achieve complete remission. However, even if these younger patients were treated intensively, more than 50% will relapse. Clinical results of patients older than 60 years are more unfavorable. Therefore, in all patients with AML, the overall survival is still low. In the past decade, several leukemia-associated antigens (LAA) have been identified in patients with acute myeloid leukemia. BAGE, BCL-2, OFA-iLRP, FLT3-ITD, G250, hTERT, PRAME, proteinase 3, RHAMM, survivin, and WT-1 are all LAAs that have been shown to induce CD8+ T-cell recognition and for some antigens also humoral immune responses. Interestingly, most of these LAAs are linked to cell cycle or proliferation. This article discusses the balance between LAA-driven leukemia cell expansion and the elimination of these cells through attacks on LAAs by the immune system. Current knowledge of the function and CD8+ T-cell recognition of LAAs is reviewed and an outlook is given on how to improve T-cell responses to LAAs in acute myeloid leukemia cells.en_GB
dc.language.isoenen
dc.publisherHighWire Pressen_GB
dc.relation.urlhttp://clincancerres.aacrjournals.org/content/14/22/7161.longen_GB
dc.rightsArchived with thanks to Clinical cancer research : an official journal of the American Association for Cancer Researchen_GB
dc.subjectacute myeloid leukaemiaen_GB
dc.subjectleukaemia associated antigensen_GB
dc.subjectcell proliferationen_GB
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshCD8-Positive T-Lymphocytes-
dc.subject.meshCell Proliferation-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Myeloid, Acute-
dc.subject.meshLymphocyte Activation-
dc.titleLeukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Internal Medicine III, University of Ulm, Ulm, Germany. jochen.greiner@uniklinik-ulm.deen_GB
dc.identifier.journalClinical cancer research : an official journal of the American Association for Cancer Researchen_GB

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