2.50
Hdl Handle:
http://hdl.handle.net/10547/223813
Title:
Androgens affect myogenesis in vitro and increase local IGF-1 expression
Authors:
Sculthorpe, Nicholas ( 0000-0001-8235-8580 ) ; Solomon, Andrew M.; Sinanan, Andrea C.M.; Bouloux, Pierre-Marc G.; Grace, Fergal; Lewis, Mark P.
Abstract:
The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.
Affiliation:
University of Bedfordshire
Citation:
Sculthorpe, N., Solomon, A.M., Sinanan, A.C., Bouloux, P.M., Grace, F., and Lewis, M.P. (2012) 'Androgens affect myogenesis in vitro and increase local IGF-1 expression', Medicine and Science in Sports and Exercise, 44(4) pp.610-5.
Journal:
Medicine and science in sports and exercise
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10547/223813
DOI:
10.1249/MSS.0b013e318237c5c0
PubMed ID:
21946153
Type:
Article
Language:
en
ISSN:
1530-0315
Appears in Collections:
Muscle Cellular and Molecular Physiology

Full metadata record

DC FieldValue Language
dc.contributor.authorSculthorpe, Nicholasen_GB
dc.contributor.authorSolomon, Andrew M.en_GB
dc.contributor.authorSinanan, Andrea C.M.en_GB
dc.contributor.authorBouloux, Pierre-Marc G.en_GB
dc.contributor.authorGrace, Fergalen_GB
dc.contributor.authorLewis, Mark P.en_GB
dc.date.accessioned2012-05-15T12:17:00Z-
dc.date.available2012-05-15T12:17:00Z-
dc.date.issued2012-04-
dc.identifier.citationSculthorpe, N., Solomon, A.M., Sinanan, A.C., Bouloux, P.M., Grace, F., and Lewis, M.P. (2012) 'Androgens affect myogenesis in vitro and increase local IGF-1 expression', Medicine and Science in Sports and Exercise, 44(4) pp.610-5.en_GB
dc.identifier.issn1530-0315-
dc.identifier.pmid21946153-
dc.identifier.doi10.1249/MSS.0b013e318237c5c0-
dc.identifier.urihttp://hdl.handle.net/10547/223813-
dc.description.abstractThe mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Medicine and science in sports and exerciseen_GB
dc.subjectAndrogenic Anabolic Steroidsen_GB
dc.subjectC760 Biomolecular Scienceen_GB
dc.titleAndrogens affect myogenesis in vitro and increase local IGF-1 expressionen
dc.typeArticleen
dc.contributor.departmentUniversity of Bedfordshireen_GB
dc.identifier.journalMedicine and science in sports and exerciseen_GB
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